1114883-97-4Relevant academic research and scientific papers
Enantioselective reactions of donor/acceptor carbenoids derived from α-aryl-α-diazoketones
Denton, Justin R.,Davies, Huw M. L.
supporting information; experimental part, p. 787 - 790 (2009/09/06)
The reaction of a variety of α-aryl-α-diazo ketones with activated olefins, catalyzed by the adamantyl glycine-derived dirhodium complex Rh2(S-PTAD)4, generates cyclopropyl ketones with high diastereoselectivity (up to >95:5 dr) and enantioselectivity (up to 98% ee). Intermolecular C-H functionalization of 1,4-cyclohexadiene by means of carbenoid-induced C-H insertion was also possible with this type of carbenoid.
