111490-36-9 Usage
Originator
Zeniplatin,American Cyanamid
(AHP)
Uses
Antineoplastic.
Manufacturing Process
The compound of 2,2-dibromomethyl-1,3-propanediol was prepared by the
method M. Saivier (et al.), Can. J. Chem; 44, 1599 (1966).
A mixture of 13.1 g of 2,2-dibromomethyl-1,3-propanediol, 6.5 g of sodium
azide and 750 ml of dimethylformamide was stirred and heated at 110°-
120°C for 20 h, then clarified and the filtrate evaporated. The residue was
extracted three times with dichloromethane. The extracts were combined and
evaporated, giving 13.65 g of 2,2-bis(azidomethyl)-1,3-propanediol,
compound with dimethylformamide.A 13.0 g portion of the 2,2-bis(azidomethyl)-1,3-propanediol was reduced
with 0.1 g of platinum dioxide in ethanol, using 50 lb of hydrogen pressure for
20 h. The mixture was then filtered and the filtrate concentrated to dryness,
giving 9.34 g of 2,2-bis(aminomethyl)-1,3-propanediol as a pale yellow oil.
A mixture of 1.34 g of 2,2-bis(aminomethyl)-1,3-propanediol, 4.15 g of
potassium dichloroplatinate and 22 ml of water was stirred for 2 h, then
cooled, the solid collected and washed three times with cold water. This solid
was recrystallized from 60 ml of hot water, giving 890.0 mg of the desired
[2,2-bis(aminomethyl)-1,3-propanediol-N,N']dichloroplatinum as beige
crystals, melting point 223°-225°C (dec.).
A mixture of 0.8 g of [2,2-bis(aminomethyl)-1,3-propanediol-
N,N']dichloroplatinum and 0.78 g of the disilver salt of 1,1-cyclobutane
dicarboxylic acid in 50 ml of water was stirred in the dark overnight and then
filtered. The filtrate was evaporated to dryness, giving 0.72 g of the desired
[2,2-bis(aminomethyl)-1,3-propanediol-N,N'][[1,1'-
cyclobutanedicarboxylato](2-)-O1,O1]platinum as a beige powder, melting
point 202°-205°C (dec.).
Therapeutic Function
Antineoplastic
Check Digit Verification of cas no
The CAS Registry Mumber 111490-36-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,4,9 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 111490-36:
(8*1)+(7*1)+(6*1)+(5*4)+(4*9)+(3*0)+(2*3)+(1*6)=89
89 % 10 = 9
So 111490-36-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H8O4.C5H14N2O2.Pt/c7-4(8)6(5(9)10)2-1-3-6;6-1-5(2-7,3-8)4-9;/h1-3H2,(H,7,8)(H,9,10);8-9H,1-4,6-7H2;
