111493-07-3

Upstream product

• 22774-67-0 4-chloro-N-prop-2-ynylaniline 
• 541-41-3 chloroformic acid ethyl ester 
• 106-47-8 4-chloro-aniline 
• 106-96-7 propargyl bromide 
• 2621-80-9 ethyl p-chlorophenylcarbamate 

Downstream Products

• 111493-24-4 3-(4-Chloro-phenyl)-5-prop-2-yn-(E)-ylidene-oxazolidin-2-one 
• 111493-15-3 3-(4-Chloro-phenyl)-5-[1-iodo-meth-(E)-ylidene]-oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis of 4-substituted-1,2-dihydroquinolines by means of gold-catalyzed intramolecular hydroarylation reaction of n-ethoxycarbonyl-n-propargylanilines

An alternative Au(I)-catalyzed synthetic route to functionalized 1,2-dihydroquinolines is reported. This novel approach is based on the use of N-ethoxycarbonyl protected-Npropargylanilines as building blocks that rapidly undergo the IMHA reaction affording the 6-endo cyclization product in good to high yields. In the presence of N-ethoxycarbonyl-N-propargyl-metasubstituted anilines, the regiodivergent cyclization at the ortho-/para-position is achieved by the means of catalyst fine tuning.

SYNTHESIS OF 5-ALKYNYLIDENE-OXAZOLIDIN-2-ONES

N-Carboethoxy-N-alkyl-propargylamines react with iodine, silver tetrafluoroborate and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to give N-alkyl-5(E)-iodomethylidene-oxazolidin-2-ones which can be converted to the corresponding 5-alkynyli