111493-52-8

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-1-methyl-1H-pyrazole-4-carbonitrile is used as a key intermediate in the synthesis of various drugs, contributing to the development of new therapeutic agents with improved efficacy and safety profiles.
Used in Agrochemical Production:
5-Chloro-1-methyl-1H-pyrazole-4-carbonitrile is also employed as an intermediate in the production of agrochemicals, playing a crucial role in the creation of effective and environmentally friendly pesticides and other agricultural products.
Used in Medicinal Chemistry:
5-Chloro-1-methyl-1H-pyrazole-4-carbonitrile serves as an important reactant in the field of medicinal chemistry, enabling the creation of new compounds with enhanced biological activities. Its unique structural features make it a valuable asset for the development of innovative pharmaceuticals and agrochemicals.

Upstream product

• 5334-41-8 5-amino-4-cyano-1-methylpyrazole 
• 57-13-6 urea 

Downstream Products

• 120162-55-2 azimsulfuron 

Relevant academic research and scientific papers

PROCESS OF PREPARATION OF AZIMSULFURON

The present disclosure provides process for preparation of azimsulfuron or its salts, isomers, and other derivatives thereof. The process involves treating a compound of formula I, with aqueous acetic acid or formic acid and chlorine gas or sodium hypochlorite in presence of hydrochloric acid in chlorinated solvents such as dichloromethane, 1,2-dichloroethane or with aqueous acetic acid and N-chlorosuccinimide or hydrogen peroxide in presence of hydrochloric acid in aqueous cyclic ether such as tetrahydrofuran, 1,4-dioxane to obtain 1-methyl-4-(2-methyl-2H-tetrazol-5-yl)-1H-pyrazole-5-sulfonyl chloride; converting the sulfonyl chloride to a sulfonamide and treating the sulfonamide with a phenyl(4,6-dimethoxypyrimidin-2-yl) carbamate to obtain azimsulfuron or its salts, isomers, and other derivatives thereof.

PROCESS OF PREPARATION OF AZIMSULFURON

The present disclosure provides process for preparation of azimsulfuron or its salts, isomers, and other derivatives thereof. The process involves treating a compound of formula I, (Formula I should be inserted here.) with aqueous acetic acid or formic acid and chlorine gas or sodium hypochlorite in presence of hydrochloric acid in chlorinated solvents such as dichloromethane, 1,2-dichloroethane or with aqueous acetic acid and N-chlorosuccinimide or hydrogen peroxide in presence of hydrochloric acid in aqueous cyclic ether such as tetrahydrofuran, 1,4-dioxane to obtain 1-methyl-4-(2-methyl-2H-tetrazol-5-yl)-1H-pyrazole-5-sulfonyl chloride; converting the sulfonyl chloride to a sulfonamide and treating the sulfonamide with a phenyl(4,6-dimethoxypyrimidin-2-yl) carbamate to obtain azimsulfuron or its salts, isomers, and other derivatives thereof.

SUBSTITUTUED PYRAZOLE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF.

The present disclosure provides a compound of formula I, its derivatives, salts, stereo-isomers, or regio-isomers thereof, useful as intermediates in preparation of sulfonamide or sulfonyl urea growth regulators or herbicides. Formula I The present disclosure further provides a process for preparing compound of formula I, its derivatives, salts, stereo-isomers, or regio-isomers thereof.

SUBSTITUTED TETRAZOLE COMPOUNDS AND PROCESS THEREOF

The present disclosure provides a compound of formula I, its derivatives, salts, stereo-isomers, or regio-isomers thereof, useful as intermediates in preparation of sulfonamide or sulfonyl urea growth regulators or herbicides. Formula I The present disclosure further provides a process for preparing compound of formula I, its derivatives, salts, stereo-isomers, or regio-isomers thereof.

Synthesis of 5-Chloropyrazoles by Chlorodiazoniation with Sulfur Dioxide

A facile synthesis of 5-chloropyrazoles 4a-e from 5-aminopyrazoles 2a-e via diazotization followed by chlorodediazoniation is described.A new application of sulfur dioxide as a catalyst was demonstrated to be the best for the chlorodediazoniation of diazonium chlorides 3a-e.