111496-54-9

Upstream product

• 111223-20-2 4-phenylbutylphosphonyl dichloride 
• 107492-16-0 (S)-2-<oxy>-6-<<(phenylmethoxy)carbonyl>amino>hexanoic acid 
• 46348-61-2 4-phenyl-butyl phosphonic acid 
• 110931-32-3 1-<(S)-2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester 
• 501-53-1 benzyl chloroformate 
• 59221-35-1 (S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid 
• 86552-32-1 (4-phenylbutyl)phosphinic acid 
• 42491-84-9 (S)-6-Amino-2-hydroxyhexanoic acid 
• 768-56-9 4-Phenylbut-1-ene 
• 111497-22-4 (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 126187-84-6 {4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester 
• 111223-21-3 {4-[(R)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester 

Downstream Products

• 111223-26-8 ceronapril 
• 111223-25-7 (S)-1-{(R)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- -proline, a novel orally active inhibitor of ACE

The synthesis of a series of orally active, phosphinyloxyacyl proline inhibitors of angiotensin converting enzyme (ACE) is described. The in vitro and in vivo ACE inhibitory activities are reported for each compound. The structure-activity relationship fo

A HIGHLY CONVERGENT PREPARATION OF PHOSPHONYLOXYACYLAMINO ACIDS:

A very simple, mild and efficient method for the preparation of phosphonyloxyacylamino acids from readily available starting materials is described.