1115035-61-4

Basic information

• Product Name: 2,6-diethylpyridin-4-ol
• Synonyms: 2,6-diethylpyridin-4-ol;4-Pyridinol, 2,6-diethyl-;2,6-DIETHYL-1H-PYRIDIN-4-ONE
• CAS NO: 1115035-61-4
• Molecular Formula: C9H13NO
• Molecular Weight: 151.20562
• Mol File: 1115035-61-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,6-diethylpyridin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-diethylpyridin-4-ol(1115035-61-4)
• EPA Substance Registry System: 2,6-diethylpyridin-4-ol(1115035-61-4)

Safety Data

• Hazardous Substances Data: 1115035-61-4(Hazardous Substances Data)

Usage

Description

2,6-diethylpyridin-4-ol, also known as collidinium, is an organic compound characterized by its molecular formula C12H19NO. It is a pyridine derivative featuring two ethyl substituents at the 2 and 6 positions, along with a hydroxy group at the 4 position. This versatile chemical is recognized for its reactivity and biological activity, making it a valuable precursor in the synthesis of pharmaceuticals and agrochemicals. It also serves as an intermediate in the production of dyes, pigments, and other organic compounds, and its antifungal and antimicrobial properties contribute to its utility in pharmaceutical product development.

Uses

Used in Pharmaceutical and Agrochemical Industries:
2,6-diethylpyridin-4-ol is used as a precursor in the synthesis of various pharmaceuticals and agrochemicals due to its versatile reactivity and biological activity, which allows for the creation of a wide range of compounds with potential therapeutic and pesticidal properties.
Used in Dye and Pigment Production:
In the dye and pigment industry, 2,6-diethylpyridin-4-ol is utilized as an intermediate for the production of dyes and pigments, contributing to the development of colorants for various applications.
Used in Antifungal and Antimicrobial Applications:
2,6-diethylpyridin-4-ol is employed for its antifungal and antimicrobial properties, making it a useful component in the development of pharmaceutical products aimed at treating infections caused by fungi and bacteria.
Used in Organic Compound Synthesis:
As an intermediate, 2,6-diethylpyridin-4-ol is used in the synthesis of other organic compounds, broadening its applications across various chemical industries.

Upstream product

• 35236-85-2 6-ethyl-3-propionyl-pyran-2,4-dione 
• 14774-14-2 2,6-diethyl-4H-pyran-4-one 

Downstream Products

• 877133-54-5 4-bromo-2,6-diethyl-pyridine 

Relevant articles and documents

Di-substituted pyridinyl aminohydantoins as potent and highly selective human β-secretase (BACE1) inhibitors

The identification of highly selective small molecule di-substituted pyridinyl aminohydantoins as β-secretase inhibitors is reported. The more potent and selective analogs demonstrate low nanomolar potency for the BACE1 enzyme as measured in a FRET assay, and exhibit comparable activity in a cell-based (ELISA) assay. In addition, these pyridine-aminohydantoins are highly selectivity (>500×) against the other structurally related aspartyl proteases BACE2, cathepsin D, pepsin and renin. Our design strategy followed a traditional SAR approach and was supported by molecular modeling studies based on the previously reported aminohydantoin 3a. We have taken advantage of the amino acid difference between the BACE1 and BACE2 at the S2′ pocket (BACE1 Pro70 changed to BACE2 Lys86) to build ligands with >500-fold selectivity against BACE2. The addition of large substituents on the targeted ligand at the vicinity of this aberration has generated a steric conflict between the ligand and these two proteins, thus impacting the ligand's affinity and selectivity. These ligands have also shown an exceptional selectivity against cathepsin D (>5000-fold) as well as the other aspartyl proteases mentioned. One of the more potent compounds (S)-39 displayed an IC50 value for BACE1 of 10 nM, and exhibited cellular activity with an EC50 value of 130 nM in the ELISA assay.

Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5, 7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5, 6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor

The HCV RNA-dependent RNA polymerase has emerged as one of the key targets for novel anti-HCV therapy development. Herein, we report the optimization of the dihydropyrone series inhibitors to improve compound aqueous solubility and reduce CYP2D6 inhibitio