1115044-68-2Relevant academic research and scientific papers
Stereoselective synthesis of chiral 2,3-disubstituted 2,3-dihydro-4(1H)- pyridones
Etayo, Pablo,Badorrey, Ramon,Diaz-de-Villegas, Maria D.,Galvez, Jose A.
, p. 6008 - 6014 (2008)
The alkylation at C-3 of the easily accessible (R)-2-[(S)-1,2- bis(benzyloxy)ethyl]-1-[(S)-1-phenylethyl]-2,3-dihydro-4(1H)-pyridone with different electrophiles took place with total trans diastereoselectivity to afford the corresponding (2R,3S)-2,3-disubstituted 2,3-dihydro-4(1H)-pyridones in enantiomerically pure form. The configuration at C-3 can be inverted by deprotonation and subsequent reprotonation to yield the corresponding (2R,3R)-2,3-disubstituted 2,3-dihydro-4(1H)-pyridones in a highly diastereoselective manner. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
