1115433-99-2Relevant academic research and scientific papers
Structure-activity relationship studies of 5-benzylaminoimidazo[1,2-c]pyrimidine-8-carboxamide derivatives as potent, highly selective ZAP-70 kinase inhibitors
Hirabayashi, Akihito,Mukaiyama, Harunobu,Kobayashi, Hiroaki,Shiohara, Hiroaki,Nakayama, Satoko,Ozawa, Motoyasu,Miyazawa, Keiji,Misawa, Keiko,Ohnota, Hideki,Isaji, Masayuki
experimental part, p. 284 - 294 (2011/02/28)
Zeta-associated protein, 70 kDa (ZAP-70), a spleen tyrosine kinase (Syk) family kinase, is normally expressed on T cells and natural killer cells and plays a crucial role in activation of the T cell immunoresponse. Thus, selective ZAP-70 inhibitors might
