1115490-85-1

Basic information

• Product Name: BenzenaMine, 3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)-
• Synonyms: BenzenaMine, 3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)-;4-((1H-Pyrazolo[3,4-b]pyridin-4-yl)oxy)-3-fluoroaniline;3-Fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)aniline
• CAS NO: 1115490-85-1
• Molecular Formula: C12H9FN4O
• Molecular Weight: 244.2244632
• Mol File: 1115490-85-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 455.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.476±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.44±0.40(Predicted)
• CAS DataBase Reference: BenzenaMine, 3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzenaMine, 3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)-(1115490-85-1)
• EPA Substance Registry System: BenzenaMine, 3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)-(1115490-85-1)

Safety Data

• Hazardous Substances Data: 1115490-85-1(Hazardous Substances Data)

Usage

Description

Benzenamine, 3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)is a chemical compound with the molecular formula C16H10FN5O. It is a fluoro-substituted derivative of 1H-pyrazolo[3,4-b]pyridin-4-yloxy and belongs to the class of organic compounds known as anilines. Benzenamine, 3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)may have potential applications in the field of pharmaceuticals and agrochemicals due to its unique structure and properties. Further research and exploration of its chemical properties and potential uses may reveal its significance in various industries.

Uses

Used in Pharmaceutical Industry:
Benzenamine, 3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)is used as a potential pharmaceutical compound for its unique structure and properties. It may be employed in the development of new drugs, particularly in the areas of medicinal chemistry and drug discovery, where its specific characteristics could contribute to the creation of novel therapeutic agents.
Used in Agrochemical Industry:
Benzenamine, 3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)is used as a potential agrochemical compound for its unique structure and properties. It may be utilized in the development of new pesticides, herbicides, or other agricultural chemicals, where its specific characteristics could contribute to the creation of more effective and environmentally friendly products.

Upstream product

• 399-96-2 4-amino-2-fluorophenol 
• 29274-28-0 4-Chloro-1H-pyrazolo<3,4-b>pyridine 

Relevant articles and documents

Discovery of small molecule FLT3 inhibitors that are able to overcome drug-resistant mutations

Herein we report the discovery of 1-(5-(tert-butyl)isoxazol-3-yl)-3- (3-fluorophenyl)urea derivatives as new FLT3 inhibitors that are able to overcome the drug resistance mutations: the secondary D835Y and F691L mutations on the basis of the internal tandem duplications (ITD) mutation of FLT3 (FLT3-ITD/D835Y and FLT3-ITD/F691L, respectively). The most potent compound corresponds to 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3- fluorophenyl)urea (4d), which showed IC50s (half maximal inhibitory concentrations) of 0.072 nM, 5.86 nM and 3.48 nM against FLT3-ITD, FLT3-ITD/F691L and FLT3-ITD/D835Y, respectively. Compound 4d also showed good selectivity for FLT3 in a kinase profiling assay. Collectively, 4d could be a good lead compound and deserves further in-depth studies.