111574-79-9Relevant academic research and scientific papers
Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions
Zhou, Yuntao,Piergentili, Irene,Hong, Jennifer,Helm, Michelle P. Van Der,MacChione, Mariano,Li, Yao,Eelkema, Rienk,Luo, Sanzhong
, p. 6035 - 6040 (2020)
Acylhydrazones formation has been widely applied in materials science and biolabeling. However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an iminium ion intermediate. This new type of catalyst showed up to 15-fold rate enhancement over the traditional anilinecatalyzed reaction at neutral conditions. The identified indoline catalyst was successfully applied in hydrogel formation.
New ampicillin derivatives with glyoxyloylbenzhydrazones as side chains
Heinisch,Hanschke,Willitzer,Mollmann,Tresselt,Stengel,Eckardt,Kleinwachter
, p. 412 - 415 (2007/10/02)
New ampicillin derivatives were synthesized from glyoxylic acid benzhydrazones by reaction with chloroformates via mixed anhydrides and ampicillin. These compounds were tested in an agar diffusion test against six different bacterial strains and also for their stability against β-lactamases. Studies about structure activity relationships have shown, that the activity against different bacterial strains is influenced in different manner by hydrophilic or hydrophobic and electronic properties of substituents.
