111581-88-5

Basic information

• Product Name: methyl (2S)-1-[(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoyl]-1,2,3,4-tetrahydropyridine-2-carboxylate
• Synonyms: 2-pyridinecarboxylic acid, 1-[(2S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4-tetrahydro-, methyl ester, (2S)-; Methyl (2S)-1-[(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoyl]-1,2,3,4-tetrahydropyridine-2-carboxylate
• CAS NO: 111581-88-5
• Molecular Formula: C₂₄H₂₂N₂O₅
• Molecular Weight: 418.4419
• Mol File: 111581-88-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 620.838°C at 760 mmHg
• Flash Point: 329.271°C
• Density: 1.335g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: methyl (2S)-1-[(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoyl]-1,2,3,4-tetrahydropyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S)-1-[(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoyl]-1,2,3,4-tetrahydropyridine-2-carboxylate(111581-88-5)
• EPA Substance Registry System: methyl (2S)-1-[(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoyl]-1,2,3,4-tetrahydropyridine-2-carboxylate(111581-88-5)

Safety Data

• Hazardous Substances Data: 111581-88-5(Hazardous Substances Data)

Upstream product

• 5458-06-0 5-(4-hydroxybutyl)hydantoin 
• 110-87-2 3,4-dihydro-2H-pyran 
• 167090-40-6 (S)-2-amino-6-hydroxy-hexanoic acid methyl ester 
• 5123-55-7 Nα-phthaloyl-L-phenylalanine 
• 142589-42-2 (S)-N-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-6-hydroxy-(S)-norleucine methyl ester 
• 6033-32-5 (S)-2-amino-6-hydroxyhexanoic acid 
• 32150-91-7 phthaloyl-L-phenylalanyl chloride 
• 116330-74-6 C₂₆H₃₀N₂O₇ 
• 142589-43-3 (S)-2-[(S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-6-oxo-hexanoic acid methyl ester 

Downstream Products

• 111581-91-0 (4S,7S,12bR)-7-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid benzhydryl ester 
• 111581-89-6 (4S,7S,12bR)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid benzhydryl ester 
• 111581-90-9 (4S,7S,12bR)-7-Amino-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid benzhydryl ester 

Relevant articles and documents

Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases

A series of tricyclic, conformationally constrained Smac mimetics have been designed, synthesized, and evaluated. The most potent compound 6 (WS-5) binds to XIAP, cIAP-1, and cIAP-2 with Ki of 18, 1.1, and 4.2 nM, respectively. Compound 6 antagonizes XIAP in a functional assay, induces cIAP-1 degradation, inhibits cell growth with an IC50 of 68 nM in the MDA-MB-231 cancer cell line, and effectively induces cancer cells to undergo apoptosis.

N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors

N-formyl hydroxylamines are provided which have the structure wherein R is H, alkyl, alkenyl, aryl-(CH2)p—, heteroaryl-(CH2)p— or cycloheteroalkyl-(CH2)p— R1is H or COR2where R2is alkyl, aryl-(CH2)p—, cycloheteroalkyl-(CH2)p—, heteroaryl-(CH2)p—, alkoxy or cycloalkyl-(CH2)p—, p is 0 to 8, and A is a dipeptide derived from an amino acid or is a conformationally restricted dipeptide mimic. The above compounds are useful in treating hypertension congestive heart failure, renal failure, and hepatic cirrhosis.