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111586-44-8

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111586-44-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 111586-44-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,5,8 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 111586-44:
(8*1)+(7*1)+(6*1)+(5*5)+(4*8)+(3*6)+(2*4)+(1*4)=108
108 % 10 = 8
So 111586-44-8 is a valid CAS Registry Number.

111586-44-8Downstream Products

111586-44-8Relevant articles and documents

Synthesis, antimicrobial and chitinase inhibitory activities of 3-amidocoumarins

Butcher, R. J.,Katiyar, Diksha,Sharma, Rajesh Kumar,Singh, Vineeta,Tiwari, Neha

, (2020)

A series of 3-amidocoumarins has been synthesized and tested in vitro for their anitimicrobial and chitinase inhibitory activities. Among these, compounds 5k, 5l, 8b–8d, 8f and 8g exhibited good antibacterial activity with MIC values in the range of 6.25–25 μg/mL against some of the tested strains while compounds 5l, 8b, 8c and 8f showed good activity against at least one or two fungal strains. Some of the assayed compounds 5d, 5k, 5l, 8b and 8c displayed significant chitinase inhibitory activity with IC50 values in the range of 3.74–5.6 μM. Among them, 5l proved to be potent chitinase inhibitor with IC50 value of 3.74 μM. To better understand the enzyme-inhibitor interactions molecular docking study of all the synthesized compounds was carried out on Aspergillus fumigatus chitinase 1W9U. The compound 5l showed high binding affinity with the receptor with binding energy value of ?8.44 Kcal/mol. This study also provides structure activity relationship (SAR) of synthesized compounds.

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