111600-83-0

Usage

Uses

Used in Pharmaceutical Research and Development:
5-bromo-4-methylthiazole is utilized as a key intermediate in the synthesis of various pharmaceuticals. It plays a crucial role in the development of new drugs due to its unique structural properties that can be incorporated into medicinal compounds to enhance their therapeutic effects.
Used in Agrochemicals:
In the agrochemical industry, 5-bromo-4-methylthiazole is used as a building block for the creation of molecules with pesticidal properties. Its incorporation into these compounds can lead to the development of more effective and targeted agrochemicals.
Used in Organic Synthesis:
As a versatile building block, 5-bromo-4-methylthiazole is employed in organic synthesis for the preparation of diverse molecules. Its unique structure allows for the creation of a wide range of functional materials with various applications.
Used in Fragrance and Flavor Industries:
Although 5-bromo-4-methylthiazole is known for its characteristic odor, it can be used in the fragrance and flavor industries as a component in complex mixtures to create specific scents or tastes, taking advantage of its distinct aromatic properties.
Safety Considerations:

InChI:InChI=1/C4H4BrNS/c1-3-4(5)7-2-6-3/h2H,1H3

Upstream product

• 693-95-8 4-Methylthiazole 
• 20485-41-0 4-methylthiazole-5-carboxylic acid 

Downstream Products

• 1218791-01-5 methyl‐5‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1,3‐thiazole 
• 111600-93-2 5-ethynyl-4-methylthiazole 
• 111600-92-1 4-Methyl-5-phenylethynyl-thiazole 
• 1428761-41-4 4-methyl-5-(tibutylstannyl)thiazole 

Relevant academic research and scientific papers

SUBSTITUTED PYRAZOLE COMPOUNDS AS TOLL RECEPTOR INHIBITORS

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Indolone derivative as well as preparation method and application thereof

The invention relates to a compound represented by formula (A) or a pharmaceutically acceptable salt, a stereoisomer, a tautomer, a polymorphic substance, a solvate, a metabolite or a prodrug thereof,and also relates to a pharmaceutical composition containing the compound. The compound can be used for treating cancer or immune system diseases.

Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

Methods for the conversion of aliphatic acids to alkyl halides have progressed significantly over the past century, however, the analogous decarboxylative bromination of aromatic acids has remained a longstanding challenge. The development of efficient methods for the synthesis of aryl bromides is of great importance as they are versatile reagents in synthesis and are present in many functional molecules. Herein we report a transition metal-free decarboxylative bromination of aromatic acids. The reaction is applicable to many electron-rich aromatic and heteroaromatic acids which have previously proved poor substrates for Hunsdiecker-type reactions. In addition, our preliminary mechanistic study suggests that radical intermediates are not involved in this reaction, which is in contrast to classical Hunsdiecker-type reactivity. Overall, the process demonstrates a useful method for producing valuable reagents from inexpensive and abundant starting materials.

THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS

The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological dise

HETEROARYL SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR INHIBITION OF GAMMA SECRETASE

Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

4-methylthiazole derivatives, their methods of preparation and the pharmaceutical compositions in which they are present

The present invention relates to novel 4-methylthiazole derivatives, to tr methods of preparation and to the pharmaceutical compositions in which they are present. According to the invention, these derivatives have the general formula STR1 in which n is e