111600-88-5Relevant articles and documents
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity
Cosford, Nicholas D. P.,Tehrani, Lida,Roppe, Jeffrey,Schweiger, Edwin,Smith, Nicholas D.,Anderson, Jeffrey,Bristow, Linda,Brodkin, Jesse,Jiang, Xiaohui,McDonald, Ian,Rao, Sara,Washburn, Mark,Varney, Mark A.
, p. 204 - 206 (2003)
2-Methyl-6-(phenylethynyl)pyridine (3), a potent noncompetitive mGlu5 receptor antagonist widely used to characterize the pharmacology of mGlu5 receptors, suffers from a number of shortcomings as a therapeutic agent, including off-target activity and poor