111608-65-2

Basic information

• Product Name: 1-[4-(5-Nitro-1H-indol-3-yl)-1-piperidinyl]ethanone
• Synonyms: 1-[4-(5-Nitro-1H-indol-3-yl)-1-piperidinyl]ethanone;1-(4-(5-Nitro-1H-indol-3-yl)piperidin-1-yl)ethanone
• CAS NO: 111608-65-2
• Molecular Formula: C15H17N3O3
• Molecular Weight: 287.31
• Mol File: 111608-65-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.322
• CAS DataBase Reference: 1-[4-(5-Nitro-1H-indol-3-yl)-1-piperidinyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(5-Nitro-1H-indol-3-yl)-1-piperidinyl]ethanone(111608-65-2)
• EPA Substance Registry System: 1-[4-(5-Nitro-1H-indol-3-yl)-1-piperidinyl]ethanone(111608-65-2)

Safety Data

• Hazardous Substances Data: 111608-65-2(Hazardous Substances Data)

Usage

General Description

1-[4-(5-Nitro-1H-indol-3-yl)-1-piperidinyl]ethanone is a chemical compound with a molecular formula C16H18N4O3. It is a yellow solid that is used as a pharmaceutical ingredient. The compound is a piperidinyl-ethanone derivative with a 5-nitro-1H-indol-3-yl group attached to the piperidine ring. It acts as a receptor antagonist and has been studied for its potential use in the treatment of various medical conditions. This chemical compound has potential pharmaceutical applications and is an important ingredient in drug development research.

Upstream product

• 111608-64-1 1-<4-(2,3-dihydro-5-nitro-1H-indol-3-yl)piperidino>ethanone 
• 111608-63-0 1-<4-(1-acetyl-2,3-dihydro-1H-indol-3-yl)piperidino>ethanone 
• 111608-62-9 1-<4-(2,3-dihydro-1H-indol-3-yl)piperidino>ethanone 
• 30030-83-2 1-<4-(1H-indol-3-yl)piperidino>ethanone 

Relevant articles and documents

Synthesis and pharmacological properties of N-[4-[4-(1H-indol-3- yl)piperidinoalkyl]-2-thiazolyl]alkanesulfonamides as novel antiallergic agents

A number of N-[4-[4-(1H-indol-3-yl)piperidinoalkyl]-2- thiazolyl]alkanesulfonamides (8-21) were synthesized and evaluated for their preventive effects on systemic anaphylaxis in guinea pigs. Structure-activity analysis revealed that methane- and ethanesulfonamide derivatives having a one to three methylene tether between the piperidine and thiazole rings exhibited potent activity but the introduction of a substituent on the indole part reduced the activity. Administration (100 mg/kg p.o.) of the four compounds 8, 9, 12, 13, together with ketotifen, oxatomide, terfenadine and azelastine as reference compounds, to mice revealed that only compound 8 caused no significant increase of the sleeping time induced by hexobarbital. In addition, compound 8 (10 mg/kg i.v.) did not change the electroencephalogram in conscious rabbits. These results led to the selection of N-[4-[4-(1H-indol-3-yl)piperidinomethyl]-2-thiazolyl]methanesulfonamide (8, FK613) for further development as a novel antiallergic agent. Clinical evaluation of FK613 is now in progress.