1116134-69-0Relevant articles and documents
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
Zhu, Yiping,Xiao, Kun,Ma, Lanping,Xiong, Bin,Fu, Yan,Yu, Haiping,Wang, Wei,Wang, Xin,Hu, Dingyu,Peng, Hongli,Li, Jingya,Gong, Qi,Chai, Qian,Tang, Xican,Zhang, Haiyan,Li, Jia,Shen, Jingkang
experimental part, p. 1600 - 1613 (2009/09/30)
To explore novel effective drugs for the treatment of Alzheimer's disease (AD), a series of dual inhibitors of acetylcholineterase (AChE) and β-secretase (BACE-1) were designed based on the multi-target-directed ligands strategy. Among them, inhibitor 28