1116152-87-4Relevant academic research and scientific papers
Asymmetric intermolecular Stetter reactions of aromatic heterocyclic aldehydes with arylidenemalonates
Enders, Dieter,Han, Jianwei
, p. 3864 - 3868 (2008)
The asymmetric Michael addition of aromatic heterocyclic aldehydes to arylidenemalonates catalyzed by N-heterocyclic carbenes is described. The ketomalonates are obtained in 84-98% yields and moderate to good enantioselectivities (30-78% ee). The enantiomeric excesses could be improved to excellent levels of up to 99% ee after a single recrystallization. Georg Thieme Verlag Stuttgart.
