1116155-67-9Relevant academic research and scientific papers
Palladium-Catalyzed Intramolecular C?H Arylation versus 1,5-Palladium Migration: A Theoretical Investigation
Misawa, Nana,Tsuda, Tomohiro,Shintani, Ryo,Yamashita, Koichi,Nozaki, Kyoko
, p. 2566 - 2572 (2018)
Theoretical investigations were carried out to elucidate the origin of chemoselectivity in the palladium-catalyzed reactions of 2-(dimethylphenylsilyl)phenyl triflates with or without an amino group at the 3-position. The selective formation of a 5,10-dihydrophenazasiline rather than a dibenzosilole from the substrate with an amino group at the 3-position could be successfully explained by proposing a new 1,5-palladium migration pathway that involves a neutral diorganopalladium(II) intermediate along with the subsequent formation of a low-energy amine-coordinated palladacycle intermediate prior to the C?N bond-forming process.
