1116571-78-8Relevant articles and documents
Azabicyclic sulfonamides as potent 11β-HSD1 inhibitors
Shah, Unmesh,Boyle, Craig D.,Chackalamannil, Samuel,Baker, Hana,Kowalski, Timothy,Lee, Julie,Terracina, Giuseppe,Zhang, Lili
scheme or table, p. 1551 - 1554 (2010/06/16)
Inhibition of 11β-HSD1 has demonstrated potential in the treatment of various components of metabolic syndrome. We wish to report herein the discovery of novel azabicyclic sulfonamide based 11β-HSD1 inhibitors. Highly potent compounds exhibiting inhibitor