111659-88-2

Basic information

• Product Name: 1-(2-naphthylsulfonyl)pyrrolidine
• Synonyms: 1-(2-naphthylsulfonyl)pyrrolidine;1-(naphthalen-2-ylsulfonyl)pyrrolidine
• CAS NO: 111659-88-2
• Molecular Formula: C14H15NO2S
• Molecular Weight: 261.3394
• Mol File: 111659-88-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-naphthylsulfonyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-naphthylsulfonyl)pyrrolidine(111659-88-2)
• EPA Substance Registry System: 1-(2-naphthylsulfonyl)pyrrolidine(111659-88-2)

Safety Data

• Hazardous Substances Data: 111659-88-2(Hazardous Substances Data)

Usage

General Description

1-(2-naphthylsulfonyl)pyrrolidine is a chemical compound that consists of a pyrrolidine ring attached to a naphthylsulfonyl group. It is commonly used as a reagent in organic synthesis, particularly in the preparation of various pharmaceutical compounds. The naphthylsulfonyl group allows for selective functionalization of the pyrrolidine ring, making it a valuable building block in the production of diverse heterocyclic compounds. Additionally, the presence of the sulfonyl group provides a site for potential chemical modifications, making 1-(2-naphthylsulfonyl)pyrrolidine a versatile reagent with a wide range of potential applications in chemical research and drug discovery.

Upstream product

• 7335-06-0 1-ethylpyrrolidine 
• 10151-46-9 2-naphthylsulfonyl hydrazide 
• 93-11-8 2-Naphthalenesulfonyl chloride 
• 91-60-1 2-Naphthalenethiol 
• 5586-15-2 bis(2-naphthyl)disulfide 
• 123-75-1 pyrrolidine 

Relevant articles and documents

Iodine-catalyzed sulfonylation of sulfonyl hydrazides with: Tert -amines: A green and efficient protocol for the synthesis of sulfonamides

This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides via the sulfonylation of sulfonyl hydrazides with tert-amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C-N bonds. In this reaction, molecular iodine was used as the catalyst and t-butyl hydroperoxide was used as the oxidant.

METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND

This invention offers an effective method of decreasing expression of apolipoprotein E and increasing expression of at least one of either LDL-receptor protein or AbcA1 protein including selecting mammalian cells expressing apoE and at least one of either LDL-receptor protein or AbcA1 protein, contacting the mammalian cell with an effective amount of a compound having general formula (I) or general formula (II) in an amount sufficient to decrease expression of the apoE and increase expression of at least one of the LDL-receptor protein or the AbcA1 protein in the mammalian cell.