1116622-98-0Relevant academic research and scientific papers
Synthesis of furoquinolines by a one-pot multicomponent cascade reaction catalyzed by platinum complexes
Barluenga, Jose,Mendoza, Abraham,Rodriguez, Felix,Fananas, Francisco J.
, p. 10892 - 10895 (2008)
The synthesis of furanquinoline derivatives by one-pot multicomponent cascade reaction with platinum complex, has been reported. The synthesis of spirofuranquinoline derivatives was carried out by using N-arylaldimines and exocyclic enol ethers, while platinum complex and Bronsted acid used as catalysts. It was found that cationic platinum complexes were appropriate catalysts for the in situ formation of enol ethers by intramolecular hydroalkoxylation reactions. This process also demonstrated one-pot three-component coupling reaction between a unit of an alkynol derivative and two units of N-arylaldimine. It was observed that this synthesis process can improve the functionalization of the furan ring and leads to diastereomerically pure furoquinoline derivatives. This process can be used for the synthesis of potentially bioactive compounds.
