1116655-96-9

Basic information

• Product Name: 4-benzyl-3-ethoxy-5-methyl-1H-pyrazole
• Synonyms: 4-benzyl-3-ethoxy-5-methyl-1H-pyrazole
• CAS NO: 1116655-96-9
• Molecular Weight: 216.283
• Mol File: 1116655-96-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-benzyl-3-ethoxy-5-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-3-ethoxy-5-methyl-1H-pyrazole(1116655-96-9)
• EPA Substance Registry System: 4-benzyl-3-ethoxy-5-methyl-1H-pyrazole(1116655-96-9)

Safety Data

• Hazardous Substances Data: 1116655-96-9(Hazardous Substances Data)

Upstream product

• 620-79-1 Ethyl 2-benzylacetoacetate 

Downstream Products

• 1147770-68-0 4-benzyl-3-ethoxy-1-(3-methoxyphenyl)-5-methyl-1H-pyrazole 
• 1147770-71-5 4-benzyl-1-(4-chlorophenyl)-5-ethoxy-3-methyl-1H-pyrazole 
• 1147770-66-8 4-benzyl-1-(4-chlorophenyl)-3-ethoxy-5-methyl-1H-pyrazole 
• 1223597-31-6 2-(4-benzyl-5-ethoxy-3-methyl-1H-pyrazol-1-yl)pyridine 
• 1223597-19-0 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)pyridine 

Relevant articles and documents

An improved preparation of 3-alkoxypyrazoles

The condensation between alkyl acetoacetates and hydrazines constitutes the very well-known Knorr synthetic method leading to pyrazol-3/5-ones. However, contemporary reports describe an alternate reaction pathway leading to low yields of 3/5-alkoxypyrazoles using hydrazine salts. No general method for the selective synthesis of 3-alkoxypyrazoles has been reported to date, hence we focused on this side reaction in an attempt to turn it into the main transformation. Depending on the starting material, various 3-alkoxypyrazoles (methoxy, ethoxy, benzyloxy, isopropoxy, allyloxy) were obtained in up to 56% yield. Georg Thieme Verlag Stuttgart.