1116670-43-9Relevant academic research and scientific papers
An Upstream By-product from Ester Activation via NHC-Catalysis Catalyzes Downstream Sulfonyl Migration Reaction
Han, Runfeng,He, Liwenze,Liu, Lin,Xie, Xingang,She, Xuegong
supporting information, p. 193 - 197 (2016/03/01)
A sequential reaction combining N-heterocyclic carbene (NHC) and N-hydroxyphthalimide (NHPI) catalysis allowed for the upstream by-product NHPI, which was generated in the NHC-catalyzed cycloaddition reaction, to act as the catalyst for a downstream nitro
Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines
Hao, Lin,Chen, Shaojin,Xu, Jianfeng,Tiwari, Bhoopendra,Fu, Zhenqian,Li, Tong,Lim, Jieyan,Chi, Yonggui Robin
supporting information, p. 4956 - 4959 (2013/10/22)
Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported.
Organocatalytic asymmetric inverse-electron-demand aza-Diels-Alder reaction of N-sulfonyl-1-aza-1,3-butadienes and aldehydes
Han, Bo,Li, Jun-Long,Ma, Chao,Zhang, Shan-Jun,Chen, Ying-Chun
supporting information; experimental part, p. 9971 - 9974 (2009/05/07)
(Chemical Equation Presented) Water is crucial for high transformation efficiency in the title reaction catalyzed by the α,α- diphenylprolinol derivative 1. Excellent stereoselectivities were observed for a broad spectrum of substrates (see scheme; TMS = trimethylsilyl, Tos = p-toluenesulfonyl). A diverse range of chiral piperidine derivatives and other valuable compounds can be prepared from the hemiaminal products.
