1116680-01-3Relevant academic research and scientific papers
The discovery of azepane sulfonamides as potent 11β-HSD1 inhibitors
Neelamkavil, Santhosh F.,Boyle, Craig D.,Chackalamannil, Samuel,Greenlee, William J.,Zhang, Lili,Terracina, Giuseppe
scheme or table, p. 4563 - 4565 (2010/04/05)
Discovery of a series of azepine sulfonamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is described. SAR studies at the 4-position of the azepane ring have resulted in the discovery of a very potent compound 30 which has
SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1
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Page/Page column 60, (2009/04/25)
In its many embodiments, the present invention relates to a novel class of substituted azepine- and diazepine-sulfonamide compounds useful to inhibit 11BETA-hydroxysteroid dehydrogenase type-1, pharmaceutical compositions containing the compounds, and met
