111709-57-0

Basic information

• Product Name: 5-[(2-nitrophenyl)hydrazinylidene]-1,3-diazinane-2,4,6-trione
• Synonyms: 5-[(2-nitrophenyl)hydrazinylidene]-1,3-diazinane-2,4,6-trione;5-[(2-nitrophenyl)hydrazono]-2,4,6(1H,3H,5H)-pyrimidinetrione;5-[2-(2-nitrophenyl)hydrazinylidene]pyrimidine-2,4,6(1H,3H,5H)-trione
• CAS NO: 111709-57-0
• Molecular Formula: C₁₀H₇N₅O₅
• Molecular Weight: 277.19308
• Mol File: 111709-57-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-[(2-nitrophenyl)hydrazinylidene]-1,3-diazinane-2,4,6-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2-nitrophenyl)hydrazinylidene]-1,3-diazinane-2,4,6-trione(111709-57-0)
• EPA Substance Registry System: 5-[(2-nitrophenyl)hydrazinylidene]-1,3-diazinane-2,4,6-trione(111709-57-0)

Safety Data

• Hazardous Substances Data: 111709-57-0(Hazardous Substances Data)

Upstream product

• 67-52-7 BARBITURIC ACID 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 118-78-5 uramil 

Relevant articles and documents

Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors

The 90 kDa ribosomal S6 kinases (RSKs), especially RSK2, have attracted attention for the development of new anticancer agents. Through structural optimization of the hit compound 1 from our previous study, a series of barbituric acid aryl hydrazone analogues were designed and synthesized as potential RSK2 inhibitors. The most potent one, compound 9, showed a higher activity against RSK2 with an IC50 value of 1.95 μM. To analyze and elucidate their structure-activity relationship, the homology model of RSK2 N-terminal kinase domain was built and molecular docking simulations were performed, which provide helpful clues to design new inhibitors with desired activities.