111711-84-3 Usage
General Description
1-(biphenyl-4-ylsulfonyl)-5-(1-methylethoxy)pyrrolidin-2-one, also known as BMS-470539, is a chemical compound with potential pharmaceutical applications. It is a pyrrolidinone derivative that acts as a selective and reversible inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4), which is involved in the regulation of blood glucose levels. By inhibiting DPP-4, BMS-470539 has potential as a treatment for type 2 diabetes, as it can increase the concentration of incretin hormones, which help to lower blood sugar levels by stimulating insulin release and inhibiting glucagon secretion. 1-(biphenyl-4-ylsulfonyl)-5-(1-methylethoxy)pyrrolidin-2-one has been studied in preclinical and clinical trials for its potential as an oral treatment for diabetes and other metabolic disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 111711-84-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,7,1 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 111711-84:
(8*1)+(7*1)+(6*1)+(5*7)+(4*1)+(3*1)+(2*8)+(1*4)=83
83 % 10 = 3
So 111711-84-3 is a valid CAS Registry Number.
111711-84-3Relevant articles and documents
Amnesia-reversal activity of a series of 5-alkoxy-1-arylsulfonyl-2-pyrrolidinones
Toja, E,Gorini, C,Zirotti, C,Barzaghi, F,Galliani, G
, p. 403 - 413 (2007/10/02)
A series of 5-alkoxy-1-arylsulfonyl-2-pyrrolidinones were prepared by condensation of arylsulfonyl chlorides with 5-alkoxy-2-pyrrolidinones.Most compounds reversed electroconvulsive shock-induced amnesia in mice, showing the typical inverted U-shaped dose
