111726-43-3

Basic information

• Product Name: 1,3-Benzodioxole, 5-(methoxymethoxy)-
• Synonyms: 1,3-Benzodioxole, 5-(methoxymethoxy)-;5-(Methoxymethoxy)benzo[d][1,3]dioxole
• CAS NO: 111726-43-3
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.1733
• Mol File: 111726-43-3.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 260.6±28.0 °C(Predicted)
• Appearance: /
• Density: 1.235±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1,3-Benzodioxole, 5-(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzodioxole, 5-(methoxymethoxy)-(111726-43-3)
• EPA Substance Registry System: 1,3-Benzodioxole, 5-(methoxymethoxy)-(111726-43-3)

Safety Data

• Hazardous Substances Data: 111726-43-3(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Faint

Uses

a. Production of fragrances and flavoring agents
b. Synthesis of pharmaceutical drugs
c. Solvent for various industrial applications

Characteristics

Enhances aromatic and sweet properties of other substances

Safety concerns

Potential health and safety risks if not handled properly

Upstream product

• 533-31-3 Sesamol 
• 107-30-2 chloromethyl methyl ether 
• 542-88-1 bis(2-chloromethyl)ether 
• 13057-17-5 bromethyl methyl ether 
• 120-57-0 piperonal 
• 80592-18-3 3,4-methylenedioxyphenyl formate 

Downstream Products

• 484-31-1 dillapiole 
• 316800-21-2 5-hydroxy-4-phenylthio-1,3-benzodioxole 
• 316800-20-1 5-hydroxy-4-phenylmethylthio-1,3-benzodioxole 
• 316800-25-6 5-allyloxy-4-phenylthio-1,3-benzodioxole 
• 316800-22-3 5-hydroxy-4-(4'-methoxyphenylthio)-1,3-benzodioxole 
• 316800-34-7 5-methoxy-4-phenylthio-6-(2-propenyl)-1,3-benzodioxole 
• 316800-24-5 5-allyloxy-4-phenylmethylthio-1,3-benzodioxole 
• 316800-31-4 5-hydroxy-4-phenylthio-6-(2-propenyl)-1,3-benzodioxole 
• 316800-26-7 5-allyloxy-4-(4'-methoxyphenylthio)-1,3-benzodioxole 
• 316800-30-3 5-hydroxy-4-phenylmethylthio-6-(2-propenyl)-1,3-benzodioxole 
• 316800-33-6 5-methoxy-4-phenylmethanethio-6-(2-propenyl)-1,3-benzodioxole 
• 316800-32-5 5-hydroxy-4-(4'-methoxyphenylthio)-6-(2-propenyl)-1,3-benzodioxole 
• 1160843-24-2 C₂₆H₂₅BrO₉ 
• 1163750-76-2 C₁₇H₁₆O₃ 

Relevant articles and documents

Design, synthesis, and evaluation of A-ring-modified lamellarin N analogues as noncovalent inhibitors of the EGFR T790M/L858R mutant

A series of A-ring-modified lamellarin N analogues were designed, synthesized, and evaluated as potential noncovalent inhibitors of the EGFR T790M/L858R mutant, a causal factor in the drug-resistant non-small cell lung cancer. Several water-soluble ammonium- or guanidinium-tethered analogues exhibited good kinase inhibitory activities. The most promising analogue, 14f, displayed an excellent inhibitory profile against the T790M/L858R mutant [IC50 (WT) = 31.8 nM; IC50 (T790M/L858R) = 8.9 nM]. The effects of A-ring-substituents on activity were rationalized by docking studies.

Enantioselective Ni-Catalyzed Electrochemical Synthesis of Biaryl Atropisomers

A scalable enantioselective nickel-catalyzed electrochemical reductive homocoupling of aryl bromides has been developed, affording enantioenriched axially chiral biaryls in good yield under mild conditions using electricity as a reductant in an undivided cell. Common metal reductants such as Mn or Zn powder resulted in significantly lower yields in the absence of electric current under otherwise identical conditions, underscoring the enhanced reactivity provided by the combination of transition metal catalysis and electrochemistry.

HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF

Described herein are compounds, including pharmaceutically acceptable salts thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat, prevent or diagnose blood-based diseases, disorders or conditions.