111756-84-4Relevant articles and documents
Indoloquinoxalines with substituents in 6-position containing cyclic groups as antiviral agents
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, (2008/06/13)
Novel indoloquinoxalines having substituents in 6-position containing cyclic groups, of the general formula I STR1 wherein R1 represents hydrogen or one or several preferably 1 to 4, similar or different substituents in the positions 1-4 and/or 7-10, selected from halogen, lower alkyl-/alkoxy group having not more than 4 carbon atoms, trifluoromethyl group, trichloromethyl group; X is a group STR2 wherein Y is CH2, NH, O or S and a is 2, 3 or 4 and wherein also the bond --C=N-- can be saturated; Z is alkyl having 1-6 carbon atoms, Cl, Br or CF3 and R3 represents hydrogen, lower alkyl-/cycloalkyl group having not more than 4 carbon atoms, and the physiologically acceptable addition products of the compounds with acids and halogen adducts are described. Also methods for preparing said compounds by reaction of a compound of the formula II STR3 with a reactive compound containing the residue --CHR3 X or by rearranging a compound of the formula III STR4 by heating, are described. The novel indoloquinoxalines have antiviral effect and have effect against cancer.
