1117684-46-4Relevant academic research and scientific papers
Rapid generation of a high quality lead for transforming growth factor-β (TGF-β) type I receptor (ALK5)
Goldberg, Frederick W.,Ward, Richard A.,Powell, Steven J.,Debreczeni, Judit é.,Norman, Richard A.,Roberts, Nicola J.,Dishington, Allan P.,Gingell, Helen J.,Wickson, Kate F.,Roberts, Andrew L.
, p. 7901 - 7905 (2009)
A novel class of 4-pyridinoxy-2-anilinopyridine-based TGF-β type I receptor (also known as activin-like kinase 5 or ALK5) inhibitors is reported. The binding mode of this scaffold was successfully predicted by analyzing possible docked binding modes of li
CHEMICAL COMPOUNDS-821
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Page/Page column 39, (2009/03/07)
The invention relates to chemical compounds of the formula (I), or pharmaceutically acceptable salts thereof, which possess ALK5 (TGFβR1) inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the
