111781-49-8 Usage
Pyrazine derivative
This chemical is derived from a pyrazine, which is a chemical structure that consists of two linked five-membered nitrogen-containing rings.
Difluoroethyl substituent
The compound has a difluoroethyl group attached to it, which is a fluorinated alkyl group with two carbon atoms.
Common uses
The chemical is commonly used in the pharmaceutical and agrochemical industries as an intermediate for the synthesis of various compounds. It is also used in the production of flavors and fragrances due to its unique aromatic properties.
Physical properties
2-(1,1-Difluoroethyl)pyrazine is a colorless liquid with a strong, sweet aroma.
Hazardous chemical
It is considered to be a potentially hazardous chemical if not handled and stored properly.
Check Digit Verification of cas no
The CAS Registry Mumber 111781-49-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,7,8 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 111781-49:
(8*1)+(7*1)+(6*1)+(5*7)+(4*8)+(3*1)+(2*4)+(1*9)=108
108 % 10 = 8
So 111781-49-8 is a valid CAS Registry Number.
111781-49-8Relevant articles and documents
Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)
Trofymchuk, Serhii,Bugera, Maksym,Klipkov, Anton A.,Ahunovych, Volodymyr,Razhyk, Bohdan,Semenov, Sergey,Boretskyi, Andrii,Tarasenko, Karen,Mykhailiuk, Pavel K.
, p. 12181 - 12198 (2021/09/13)
A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.
