111782-25-3

Basic information

• Product Name: Thiourea, N-1-naphthalenyl-N'-(4-nitrophenyl)-
• CAS NO: 111782-25-3
• Molecular Formula: C17H13N3O2S
• Molecular Weight: 323.375
• Mol File: 111782-25-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Thiourea, N-1-naphthalenyl-N'-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-1-naphthalenyl-N'-(4-nitrophenyl)-(111782-25-3)
• EPA Substance Registry System: Thiourea, N-1-naphthalenyl-N'-(4-nitrophenyl)-(111782-25-3)

Safety Data

• Hazardous Substances Data: 111782-25-3(Hazardous Substances Data)

Upstream product

• 42882-31-5 (RS)-1-(1-naphthyl)ethylamine 
• 2131-61-5 p-nitrophenyl isothiocyanate 
• 134-32-7 1-amino-naphthalene 
• 552-46-5 1-naphthylamine hydrochloride 

Relevant articles and documents

Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents

Ten p-nitrodiarylthiourea analogs were designed, synthesized and evaluated in breast (MCF-7, T-47D, MDA-MB-453) and prostate (DU-145, PC-3, LNCaP) cancer cell lines for their anticancer activities. The majority of the compounds were able to inhibit the growth of these six cancer cell lines at low micromolar concentrations. Compound 7 was found to be the most potent anticancer agent in this series with GI50 values of 3.16 μM for MCF-7, 2.53 μM for T-47D, 4.77 μM for MDA-MB-453 breast cancer lines and 3.54 μM for LNCaP prostate cancer cell line. These GI50 values were comparable to the parent compound, SHetA2.