111787-91-8

Basic information

• Product Name: (2-METHYL-5-PHENYL-3-FURYL)METHANOL
• Synonyms: RARECHEM AL BD 0515;(2-METHYL-5-PHENYL-3-FURYL)METHANOL;(2-METHYL-5-PHENYLFURAN-3-YL)METHANOL;3-(Hydroxymethyl)-2-methyl-5-phenylfuran;(2-Methyl-5-phenylfur-3-yl)methanol
• CAS NO: 111787-91-8
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.22
• Mol File: 111787-91-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 22-23
• Boiling Point: 127 °C
• Flash Point: 95.2°C
• Appearance: /
• Density: 1.123g/cm³
• Vapor Pressure: 0.0302mmHg at 25°C
• Refractive Index: 1.562
• PKA: 14.11±0.10(Predicted)
• CAS DataBase Reference: (2-METHYL-5-PHENYL-3-FURYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-METHYL-5-PHENYL-3-FURYL)METHANOL(111787-91-8)
• EPA Substance Registry System: (2-METHYL-5-PHENYL-3-FURYL)METHANOL(111787-91-8)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 111787-91-8(Hazardous Substances Data)

Usage

General Description

(2-Methyl-5-phenyl-3-furyl)methanol is a chemical compound that belongs to the furan derivatives family. It is an organic compound with a molecular formula C13H12O2 and a molecular weight of 200.23 g/mol. (2-METHYL-5-PHENYL-3-FURYL)METHANOL is commonly used as a building block in organic synthesis and in the production of various pharmaceuticals, agrochemicals, and fine chemicals. It has been studied for its potential pharmacological activities, including its anti-inflammatory and analgesic properties. Additionally, it is known for its pleasant odor and is used in the formulation of perfumes and fragrances. Overall, (2-Methyl-5-phenyl-3-furyl)methanol has versatile applications and is an important chemical in the field of organic chemistry and pharmaceuticals.

InChI:InChI=1/C12H12O2/c1-9-11(8-13)7-12(14-9)10-5-3-2-4-6-10/h2-7,13H,8H2,1H3

Upstream product

• 70-11-1 α-bromoacetophenone 
• 52313-46-9 ethyl 2-acetyl-4-oxo-4-phenylbutanoate 
• 175276-57-0 5-phenyl-2-methyl-3-furoyl chloride 
• 29113-64-2 ethyl 2-methyl-5-phenylfuran-3-carboxylate 

Downstream Products

• 321309-42-6 2-methyl-5-phenylfuran-3-carbaldehyde 

Relevant articles and documents

Photochemical Alkene Isomerization for the Synthesis of Polysubstituted Furans and Pyrroles under Neutral Conditions

A photochemical approach to polysubstituted heterocycles using UV-induced alkene isomerization is described. The method allows for the synthesis of disubstituted furans and pyrroles under mild and neutral conditions and also provides access to a class of trisubstituted furans pertinent to natural-product synthesis. The method has broad functional-group tolerance and many richly decorated heterocycles have been prepared incorporating functional groups that are unstable under Br?nsted and Lewis acidic conditions.

Halomethyl derivatives of 2-phenylfurans in the Arbuzov and Michaelis-Becker reactions

The α-phenyl substituent in 3-(chloromethyl)furan, nonconjugated with the reaction center, does not hinder the nucleophilic attack of phosphite anion under conditions of the Michaelis-Becker reaction, while in the isomer with a conjugated phenyl substituent the halogen atom is attacked under the same conditions. Reaction of the latter with trimethyl phosphite yields the corresponding phosphonate. Phosphorylation of 5-(bromomethyl)-2-phenylfuran derivatives containing acceptor substituents in the β-position of the furan ring with trimethyl phosphite in the presence of amyl alcohol as proton donor involves no attack of the phosphite on the halogen atom and the products of the classic Arbuzov reaction are formed.