111810-41-4

Usage

Uses

Due to the highly toxic nature of 4'-OH-3,3',4,5'-TetraCB, its use is generally prohibited or severely restricted in many countries. However, it is important to be aware of its presence in various sources such as industrial processes, waste incineration, and contaminated soil and water to mitigate its impact on the environment and human health.
Used in Environmental Monitoring and Remediation:
4'-OH-3,3',4,5'-TetraCB is used as a target pollutant in environmental monitoring programs to assess the level of contamination in various ecosystems. This helps in identifying areas that require remediation efforts to reduce the presence of this toxic chemical and protect both the environment and human health.
Used in Research and Toxicological Studies:
4'-OH-3,3',4,5'-TetraCB is used as a subject of research in toxicological studies to better understand its effects on human and animal health, as well as to develop methods for its detection, prevention, and treatment. This knowledge aids in the development of regulations and guidelines to minimize exposure to this harmful chemical.

Upstream product

• 32598-13-3 33'44'-tetrachlorinated biphenyl 

Relevant academic research and scientific papers

β-Naphthoflavone- and self-induced metabolism of 3,3',4,4'-tetrachlorobiphenyl in hepatic microsomes of the male, pregnant female and foetal rat

1. The in vitro metabolism of 3,3',4,4'-tetrachloro-[14C]-biphenyl ([14C]-TCB) by hepatic microsomes from the Wistar rat was investigated with liver microsomes from the male, pregnant female and foetus. 2. Three hydroxylated metabolites (4-OH-3,3',4,5'-tetrachlorobiphenyl, 5-OH-3,3',4,4'-tetrachlorobiphenyl, and 6-OH-3,3',4,4'-tetrachlorobiphenyl) were identified by hplc and gc-ms after incubations of liver microsomes from the β-naphthoflavone-pretreated male rat and TCB-treated pregnant rat. No metabolites of [14C]-TCB were found after incubation with foetal liver microsomes from dams pretreated with [14C]-TCB. The results indicate that the in vivo accumulation of 4-OH-tetraCB in the foetal compartment is probably due to transplacental transport rather than the formation of this metabolite in the foetus. 3. Pretreatment of the male rat with β-naphthoflavone substantially induced the formation of hydroxylated metabolites, but pretreatment with phenobarbital and dexamethasone was without effect. Based on in vitro incubations of liver microsomes from the β-naphthoflavone pretreated male rat, an apparent K(m) and V(max) of 4.5 μM and 240 pmol/mg protein/min respectively was determined for the metabolism of [14C]-TCB. The formation of phenolic metabolites of [14C]-TCB was most likely dependent on P4501A induction.