111810-41-4

Basic information

• Product Name: 4'-OH-3,3',4,5'-TetraCB
• Synonyms: 4'-OH-3,3',4,5'-TetraCB
• CAS NO: 111810-41-4
• Molecular Formula: C12H6Cl4O
• Molecular Weight: 307.98744
• Mol File: 111810-41-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 385.1 °C at 760 mmHg
• Flash Point: 186.7 °C
• Appearance: /
• Density: 1.532 g/cm³
• PKA: 6.36±0.40(Predicted)
• CAS DataBase Reference: 4'-OH-3,3',4,5'-TetraCB(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-OH-3,3',4,5'-TetraCB(111810-41-4)
• EPA Substance Registry System: 4'-OH-3,3',4,5'-TetraCB(111810-41-4)

Safety Data

• Hazardous Substances Data: 111810-41-4(Hazardous Substances Data)

Usage

General Description

4'-OH-3,3',4,5'-TetraCB, also known as 4'-hydroxy-3,3',4,5'-tetrachlorobiphenyl, is a type of polychlorinated biphenyl (PCB) that belongs to the class of persistent organic pollutants. This chemical is a highly toxic and persistent environmental contaminant that can be found in various sources, including industrial processes, waste incineration, and contaminated soil and water. 4'-OH-3,3',4,5'-TetraCB has been linked to a number of health effects in humans and animals, including developmental and reproductive problems, immune system disorders, and potential carcinogenic effects. Due to its persistence and toxicity, 4'-OH-3,3',4,5'-TetraCB has been banned or severely restricted in many countries, but it continues to be a concern for environmental and human health.

Upstream product

• 32598-13-3 33'44'-tetrachlorinated biphenyl 

Relevant articles and documents

β-Naphthoflavone- and self-induced metabolism of 3,3',4,4'-tetrachlorobiphenyl in hepatic microsomes of the male, pregnant female and foetal rat

1. The in vitro metabolism of 3,3',4,4'-tetrachloro-[14C]-biphenyl ([14C]-TCB) by hepatic microsomes from the Wistar rat was investigated with liver microsomes from the male, pregnant female and foetus. 2. Three hydroxylated metabolites (4-OH-3,3',4,5'-tetrachlorobiphenyl, 5-OH-3,3',4,4'-tetrachlorobiphenyl, and 6-OH-3,3',4,4'-tetrachlorobiphenyl) were identified by hplc and gc-ms after incubations of liver microsomes from the β-naphthoflavone-pretreated male rat and TCB-treated pregnant rat. No metabolites of [14C]-TCB were found after incubation with foetal liver microsomes from dams pretreated with [14C]-TCB. The results indicate that the in vivo accumulation of 4-OH-tetraCB in the foetal compartment is probably due to transplacental transport rather than the formation of this metabolite in the foetus. 3. Pretreatment of the male rat with β-naphthoflavone substantially induced the formation of hydroxylated metabolites, but pretreatment with phenobarbital and dexamethasone was without effect. Based on in vitro incubations of liver microsomes from the β-naphthoflavone pretreated male rat, an apparent K(m) and V(max) of 4.5 μM and 240 pmol/mg protein/min respectively was determined for the metabolism of [14C]-TCB. The formation of phenolic metabolites of [14C]-TCB was most likely dependent on P4501A induction.