111818-56-5Relevant articles and documents
Method of preparing N-acryloyl-α-amino acids
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, (2008/06/13)
A novel, one-pot procedure for the preparation of N-acryloyl-α-amino acids involves the steps of: (i) reacting a ketone, an ammonium salt, and a cyanide salt in water, optionally in the presence of ammonium hydroxide and a co-solvent, to form an aminonitrile; (ii) acryloylating the aminonitrile in aqueous media to afford an acrylamidonitrile; and (iii) hydrolyzing with aqueous acid the acrylamidonitrile to provide the N-acryloyl-α-amino acid.