111827-69-1 Usage
Type of compound
Ketone
Backbone structure
Phenanthrene
Substituents
Ethyl group, several methyl groups
Stereochemistry
(4aR,4bS,8aS)
Potential applications
Organic synthesis, chemical research
Further study needed
Properties and potential uses
Type of compound (Ketone)
It is a ketone, which means it has a carbonyl group (C=O) bonded to two carbon-containing groups.
Backbone structure (Phenanthrene)
The phenanthrene backbone is a fused ring system consisting of three six-membered rings, which forms the core structure of this compound.
Substituents (Ethyl group, several methyl groups)
The compound has an ethyl group (C2H5) and several methyl groups (CH3) attached to the phenanthrene backbone, which influence its chemical properties and reactivity.
Stereochemistry ((4aR,4bS,8aS))
The stereochemistry of the compound is specified by the (4aR,4bS,8aS) designation, which indicates the spatial arrangement of the substituents on the molecule. This is important for understanding the compound's properties and potential applications.
Potential applications (Organic synthesis, chemical research)
This compound may be useful in organic synthesis, which involves the construction of complex organic molecules from simpler precursors, and in chemical research to study its properties and potential applications.
Further study needed (Properties and potential uses)
More research and study are required to fully understand the properties and potential uses of this chemical compound, as it is a complex structure with specific stereochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 111827-69-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,8,2 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 111827-69:
(8*1)+(7*1)+(6*1)+(5*8)+(4*2)+(3*7)+(2*6)+(1*9)=111
111 % 10 = 1
So 111827-69-1 is a valid CAS Registry Number.
111827-69-1Relevant articles and documents
The synthesis and antibacterial activity of totarol derivatives. Part 1: Modifications of ring-C and pro-drugs
Evans, Gary B.,Furneaux, Richard H.,Gravestock, Michael B.,Lynch, Gregory P.,Scott, G.Kenneth
, p. 1953 - 1964 (2007/10/03)
A series of analogues of, and potential pro-drugs derived from, the potent antibacterial diterpene totarol (1) were synthesized in order to elucidate the minimum structural requirements for antibacterial activity and to seek compounds with good bioavailability in vivo. These analogues varied in the structural features of their aromatic rings and the prodrugs were O-glycosylated derivatives. They were tested in vitro against three Gram-positive bacteria: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus (MRSA); and against the Gram-negative multi-drug-resistant Klebsiella pneumoniae. None of the analogues was more potent than totarol itself, which is effective against these Gram-positive bacteria at MIC values of 7 μM. The results were evaluated in terms of a structure-activity relationship and this showed that a phenolic moiety was essential for potent antibacterial activity. Amongst the pro-drugs, totaryl α-D-mannopyranoside (22) proved the most active in vitro (MIC 18 μM). The in vivo antibacterial activities of compounds 1, 22 and totarol β-lactoside (23) were assessed in a mouse model of infection, but they were found to be ineffective. Compounds 1 and 22 were shown to be cytotoxic towards proliferating human cell cultures, CH 2983, HeLa, and MG 63, but only at concentrations of > 30 μM.
