111829-15-3Relevant academic research and scientific papers
Palladium and visible-light mediated carbonylative Suzuki-Miyaura coupling of unactivated alkyl halides and aryl boronic acids
Roslin, Sara,Odell, Luke R.
supporting information, p. 6895 - 6898 (2017/07/10)
Herein, a simple and efficient method for the palladium-catalyzed carbonylation of aryl boronic acids with unactivated alkyl iodides and bromides under visible-light irradiation, ambient temperature and low CO-pressure is presented. Notably, the procedure uses readily available equipment and an inexpensive palladium catalyst to generate the key alkyl radical intermediate. These mild conditions enabled the synthesis of a range of functionalized aryl alkyl ketones including the antipsychotic drug, melperone.
α-Arylation, α-arylative esterification, or acylation: A stoichiometry-dependent trichotomy in the Pd-catalyzed cross-coupling between aldehydes and aryl bromides
Nareddy, Pradeep,Mazet, Clement
supporting information, p. 2579 - 2583 (2013/11/19)
Three′s company: The selective α-arylation and α-arylative esterification of linear and branched aldehydes is reported for a variety of bromoarenes. The acylation of aryl bromides can be achieved with linear aldehydes (see scheme). All these transformations were performed with a single [(N-heterocyclic carbene)Pd] catalyst through adjustment of the stoichiometry of the reagents and the appropriate base. Copyright
Synthesis of aryl fluorides on a solid support and in solution by utilizing a fluorinated solvent
Doebele, Marion,Vanderheiden, Sylvia,Jung, Nicole,Braese, Stefan
supporting information; experimental part, p. 5986 - 5988 (2010/10/01)
(Figure Presented) F for fast: The perfluorinated solvent C 6F14 is the key to a new variant of the BalzSchiemann reaction for the synthesis of fluorinated arenes. Triazenes are converted into fluoroarenes under mild con-ditions on a support and in solution (see scheme). The method is straightforward and inexpensive, and yields previously difficult-to-prepare fluoroarenes in high purity.
Iron catalyst for oxidation in water: Surfactant-type iron complex-catalyzed mild and efficient oxidation of aryl alkanes using aqueous TBHP as oxidant in water
Nagano, Takashi,Kobayashi, Shu
supporting information; experimental part, p. 1042 - 1043 (2009/12/02)
Surfactant-type iron(III) complex, Fe2O(DS)4, was found to be effective for benzylic oxidation of simple aryl alkanes using aqueous t-butyl hydroperoxide (TBHP) as an oxidant. Copyright
Highly efficient chromium-catalyzed oxidation of secondary benzylic alcohols by aqueous 70% tert-butyl hydroperoxide
Muzart,N'Ait Ajjou
, p. 785 - 787 (2007/10/02)
The oxidation of secondary benzylic alcohols to ketones by the chromium(VI) oxide/tert-butyl hydroperoxide system is compatible with the presence of methyl, halide, methoxy, acetoxy or nitro substituents on the aryl group and of an unsaturation on the alkyl side chain. Benzyl alcohol led to a mixture of benzaldehyde and benzoic acid.
