111851-98-0

Basic information

• Product Name: 1H-Imidazole-2-carboxaldehyde,1-ethyl-(9CI)
• Synonyms: 1H-Imidazole-2-carboxaldehyde,1-ethyl-(9CI);1-ethyl-1H-imidazole-2-carbaldehyde(SALTDATA: FREE);1H-IMidazole-2-carboxaldehyde, 1-ethyl-;1-Ethyl-1H-imidazole-2-carboxaldehyde;1-Ethylimidazole-2-carboxaldehyde;N-Ethyl-2-imidazolecarboxaldehyde;1-ethyl-2-imidazolecarboxaldehyde;1-ethylimidazole-2-carbaldehyde
• CAS NO: 111851-98-0
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.142
• Product Categories: AMINETERTIARY
• Mol File: 111851-98-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 258℃
• Flash Point: 110℃
• Appearance: /Solid
• Density: 1.10
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 4.29±0.31(Predicted)
• CAS DataBase Reference: 1H-Imidazole-2-carboxaldehyde,1-ethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-2-carboxaldehyde,1-ethyl-(9CI)(111851-98-0)
• EPA Substance Registry System: 1H-Imidazole-2-carboxaldehyde,1-ethyl-(9CI)(111851-98-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 111851-98-0(Hazardous Substances Data)

Usage

General Description

1H-Imidazole-2-carboxaldehyde,1-ethyl-(9CI) is a chemical compound with the molecular formula C7H8N2O. It is an imidazole derivative with a carboxaldehyde group and an ethyl substituent attached to the nitrogen atom. 1H-Imidazole-2-carboxaldehyde,1-ethyl-(9CI) is used in organic synthesis and pharmaceutical research as a building block for the construction of various biologically active molecules. It has also been investigated for its potential antibacterial and antifungal properties. Additionally, it has been studied for its potential application in the development of drugs for the treatment of diseases such as cancer and diabetes. Its precise properties and potential applications depend on the specific context and the other compounds with which it is combined.

Upstream product

• 75-03-6 ethyl iodide 
• 10111-08-7 2-imidazolecarbaldehyde 
• 7098-07-9 N-Ethylimidazole 
• 13750-81-7 N-methyl-2-imidazolcarboxaldehyde 
• 74-88-4 methyl iodide 
• 74-96-4 ethyl bromide 
• 288-32-4 1H-imidazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 63634-44-6 1-ethyl-2-(hydroxymethyl)-1H-imidazole 
• 7369-51-9 dibenzylphosphinic acid 
• 475475-56-0 1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 548463-11-2 3-(1-ethylimidazol-2-yl)methyleneaminopyridine 
• 548463-15-6 2-(1-ethylimidazol-2-yl)methyleneaminopyridine 
• 902138-01-6 2-[bis(2-phenylethyl)thiophosphorylhydroxymethyl]-1-ethylimidazole 
• 497853-80-2 4-{[(1-ethyl-1H-imidazol-5-yl)methyl]sulfanyl}aniline 
• 497852-90-1 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-ethyl-1H-imidazol-2-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 497852-91-2 7-[4-(2-butoxyethoxy)phenyl]-N-[4-[[(1-ethylimidazol-2-yl)methyl]sulfinyl]phenyl]-1-isobutyl-2,3-dihydro-1-benzazepine-4-carboxamide 
• 135206-88-1 2-chloromethyl-1-ethyl-1H-imidazole hydrochloride 
• 1207454-93-0 ethyl 3-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 1207454-25-8 methyl 3-(1-ethyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 132567-16-9 RS115C 

Relevant articles and documents

CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

An object of the present invention is to provide a compound exerting an analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. The present invention provides a cyclic amine derivative represented by the following general formula, or a pharmacologically acceptable salt thereof.

Structure-Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents

Forty-three 1,5-diheteroaryl-1,4-pentadien-3-ones were designed as potential curcumin mimics, structurally featuring a central five-carbon dienone linker and two identical nitrogen-containing aromatic rings. They were synthesized using a Horner-Wadsworth-Emmons reaction as the critical step and evaluated for their cytotoxicity and antiproliferative activities toward both androgen-insensitive and androgen-sensitive prostate cancer cell lines and an aggressive cervical cancer cell line. Most of the synthesized compounds showed distinctly better in vitro potency than curcumin in the four cancer cell lines. The structure-activity data acquired from the study validated (1E,4E)-1,5-dihereroaryl-1,4-pentadien-3-ones as an excellent scaffold for in-depth development for clinical treatment of prostate and cervical cancers. 1-Alkyl-1H-imidazol-2-yl, ortho pyridyl, 1-alkyl-1H-benzo[d]imidazole-2-yl, 4-bromo-1-methyl-1H-pyrazol-3-yl, thiazol-2-yl, and 2-methyl-4-(trifluoromethyl)thiazol-5-yl were identified as optimal heteroaromatic rings for the promising in vitro potency. (1E,4E)-1,5-Bis(2-methyl-4-(trifluoromethyl)thiazol-5-yl)penta-1,4-dien-3-one, featuring thiazole rings and trifluoromethyl groups, was established as the optimal lead compound because of its good in vitro potency and attractive in vivo pharmacokinetic profiles. (Chemical Equation Presented).

METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)

Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.