111854-80-9

Upstream product

• 70853-26-8 N-carbobenzoxy-L-leucinal 
• 88738-78-7 bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate 
• 58889-73-9 (S)-N-benzyloxycarbonyl-leucine ethyl ester 

Downstream Products

• 49642-07-1 statine 
• 111854-91-2 ((1S,2S)-2,4-Dihydroxy-1-isobutyl-butyl)-carbamic acid benzyl ester 
• 93287-37-7 (3S,4S)-4-(carbamic acid benzyl ester)-3-hydroxy-6-methyl-heptanoic acid 
• 111854-84-3 ((Z)-(S)-4-Hydroxy-1-isobutyl-but-2-enyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

A stereoselective synthesis of (3S,4S) statine and related compounds

(3S,4S)Statine and (3S,4S)AHPPA were synthesized efficiently using a highly stereoselective iodocyclocarbamation of the chiral Z-olefins 6 and 6b derived from the correspondent α-aminoacids.

Diastereoselective Epoxidation of cis-4-Amino Allylic Alcohol with m-Chloroperbenzoic acid. An Efficient Synthesis of Statine

High diastereoselective epoxidation of cis-4-amino allylic alcohol (3) with m-chloroperbenzoic acid is described and the reaction is applied to the stereoselective synthesis of the β-hydroxy-γ-amino acid, statine.