1119-46-6

Basic information

• Product Name: 5-Chlorovaleric acid
• Synonyms: CVA;Anti-Integrin β5, C-Terminal antibody produced in rabbit;ITGB5;5-Chlorovaleric acid >=98.0% (GC);5-CHLOROVALERIC ACID;5-CHLORO-N-VALERIC ACID;5-CHLOROPENTANOIC;5-CHLOROPENTANOIC ACID
• CAS NO: 1119-46-6
• Molecular Formula: C₅H₉ClO₂
• Molecular Weight: 136.58
• EINECS: 214-279-3
• Product Categories: API Intermediate;omega-Chlorocarboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides
• Mol File: 1119-46-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 18 °C(lit.)
• Boiling Point: 136 °C / 14mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.170 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0227mmHg at 25°C
• Refractive Index: n20/D 1.454(lit.)
• Storage Temp.: 2-8°C
• Solubility: Chloroform, DMSO, Ethyl Acetate
• PKA: 4?+-.0.10(Predicted)
• BRN: 1745183
• CAS DataBase Reference: 5-Chlorovaleric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chlorovaleric acid(1119-46-6)
• EPA Substance Registry System: 5-Chlorovaleric acid(1119-46-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3265
• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 1119-46-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless or light color clear liquid

Uses

Different sources of media describe the Uses of 1119-46-6 differently. You can refer to the following data:
1. Labelled α-Ergocryptine. α-Ergocryptine is an ergopeptine and one of the ergot alkaloids. An impurity of 2-Bromo-α-Ergocryptine Mesylate (B682600).
2. 5-Chlorovaleric acid was used to derivatize L-hydroxyproline for the synthesis of haptens HP1 and HP2. These haptens were used in the preparation of antibodies against L-hydroxyproline.

Definition

ChEBI: An organochlorine compound comprising pentanoic acid with a 5-chloro substituent.

InChI:InChI=1/C5H9ClO2/c6-4-2-1-3-5(7)8/h1-4H2,(H,7,8)

Upstream product

• 675-20-7 piperidin-2-one 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 2677-33-0 1,1,5-trichloro-pent-1-ene 
• 120-92-3 cyclopentanone 
• 732-26-3 2,4,6-tri-tert-butylphenoxol 
• 94161-44-1 5-chloropervaleric acid 
• 626-97-1 pentamide 
• 32195-55-4 5,10,15,20-tetraphenyl-21 H,23-H-porphine manganese(III)chloride 
• 22692-45-1 methyl 5-chloropentyl ether 
• 5259-98-3 5-chloropentan-1-ol 
• 2467-10-9 1,1,1,5-tetrachloropentane 
• 109-52-4 valeric acid 
• 159087-42-0 2-(5-chloropent-1-yn-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 14267-92-6 1-chloro-4-pentyne 

Downstream Products

• 14273-86-0 methyl 5-chloropentanoate 
• 2323-81-1 ethyl 5-chloropentanoate 
• 334-75-8 1-chloro-13-fluoro-tridecane 
• 675-20-7 piperidin-2-one 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 5259-98-3 5-chloropentan-1-ol 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 19448-36-3 5-iodopentanoic acid 
• 2270-20-4 5-Phenylpentanoic acid 
• 70543-40-7 i-Pentyl ω-Chlorvaleriat 
• 2162-99-4 1,8-dichlorooctane 
• 30098-17-0 5-(2',5'-dimethylphenyl)pentanoic acid 
• 110-56-5 1,4-dichlorobutane 
• 2067-33-6 5-bromopentanoic acid 

Relevant articles and documents

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Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides

A general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)?B bond oxidation. This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcohols, and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodology was further highlighted by the preparation of pharmaceutical molecules.

A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents

A mild oxidation method for the conversion of aldoximes to carboxylic acids was developed mediated by hypervalent iodine reagents. This method covers a wide range of functionalized aldoximes and proceeds under mild conditions, utilizing PhI(OH)OTs as an oxidant.