1119249-26-1Relevant articles and documents
Multivalent iminosugars to modulate affinity and selectivity for glycosidases
Diot, Jennifer,Garcia-Moreno, M. Isabel,Gouin, Sebastien G.,Mellet, Carmen Ortiz,Haupt, Karsten,Kovensky, Jose
experimental part, p. 357 - 363 (2009/03/11)
A series of mono-, di- and tri-valent iminosugars based on oligoethylene scaffolds and N-substituted deoxynojirymicin epitopes have been synthesized by "click chemistry" to study the effect of multivalency on glycosidase inhibition. Biological evaluation evidenced differences in the inhibition trends as a function of the enzyme nature. The results demonstrate that multivalency can be used in some case to modulate both the affinity and the selectivity of glycosidase inhibition.