1119280-95-3Relevant academic research and scientific papers
Highly efficient formal synthesis of cephalotaxine, using the stevens rearrangement-acid lactonization sequence as a key transformation
Sun, Mo-Ran,Lu, Hong-Tao,Wang, Yan-Zhi,Yang, Hua,Liu, Hong-Min
experimental part, p. 2213 - 2216 (2009/08/07)
Cephalotaxine (1), the major alkaloid isolated from Cephalotaxus species, has attracted considerable attention due to the promising antitumor activity of several of its derivatives and its unique structural features. Herein we describe a highly efficient formal synthesis of 1 employing the [2,3]-Stevens rearrangement-acid lactonization sequence as a key transformation from readily available (3,4-dimethoxyphenyl)acetic acid, methyl prolinate, and allyl bromide.
Facile synthesis of 1H, 4H-cyclopenta[c]pyrrolo[1,2-b]isoquinolin-2(3H)-one
Sun, Mo Ran,Lu, Hong Tao,Yang, Hua
experimental part, p. 255 - 257 (2009/12/03)
A novel and facile method for the synthesis of 4H-cyclopenta[c]pyrrolo[1,2- b] isoquinolin-2(3H)-one has been developed by employing the [2, 3] Stevens rearrangement of methyl N-allyl-N-benzylpyrrolidine 2-carboxylate to methyl 2-allyl-l-benzyl-pyrrolidin
