1119299-57-8Relevant articles and documents
Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)
Sidique, Shyama,Ardecky, Robert,Su, Ying,Narisawa, Sonoko,Brown, Brock,Millan, Jose Luis,Sergienko, Eduard,Cosford, Nicholas D.P.
experimental part, p. 222 - 225 (2009/05/07)
Tissue-nonspecific alkaline phosphatase (TNAP) plays a central role in regulating extracellular matrix calcification during bone formation and growth. High-throughput screening (HTS) for small molecule TNAP inhibitors led to the identification of hits in