111931-85-2Relevant academic research and scientific papers
Preparation of bis(2-pyridyl) diselenide derivatives: Synthesis of selenazolo[5,4-b]pyridines and unsymmetrical diorganyl selenides, and evaluation of antioxidant and anticholinesterasic activities
Peglow, Thiago J.,Schumacher, Ricardo F.,Cargnelutti, Roberta,Reis, Angélica S.,Luchese, Cristiane,Wilhelm, Ethel A.,Perin, Gelson
, p. 3734 - 3738 (2017)
We describe here an alternative method to prepare bis(2-pyridyl) diselenide derivatives using reduced selenium species, generated in situ, and different 2-chloropyridines promoted by p-TSOH in PEG-400 as solvent. This is a straightforward protocol to prepare bis(3-amino-2-pyridyl) diselenides unprecedented to date. Still, this article describe the employment of synthesized bis(3-amino-2-pyridyl) diselenide and a diverse array of aryl aldehydes to afford the corresponding 2-aryl-selenazolo[5,4-b]pyridines in satisfactory yields and, in a short reaction time under basic condition. Furthermore, when the bis(3-amino-2-pyridyl) diselenide reacted with aliphatic halides, in the presence of NaBH4, a wide range of unsymmetrical diorganyl selenides was obtained. To complete this investigation the bis(3-amino-2-pyridyl) diselenide was evaluated for its inhibitory effect on the acetylcholinesterase (AChE) activity and free radical-scavenging capacity. Results demonstrated that this compound was antioxidant and inhibitor of the AChE activity, being a promising therapeutic agent for the treatment of Alzheimer's disease and other neurodegenerative disorders.
A Convenient Synthesis of the Previously Unattainable 2-Arylselenazolopyridines
Couture, Axel,Grandclaudon, Pierre,Huguerre, Eric
, p. 363 - 364 (2007/10/02)
Selenazopyridines, a class of previously unknown fused polyheterocycles, can be conveniently prepared by reacting selenoesters with the lithium derivative of various aminochloropyridines.The 2-aryl, - and - examples of the series have
