111934-06-6

Basic information

• Product Name: 4-Morpholinecarboxylic acid, 3-bromo-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-
• CAS NO: 111934-06-6
• Molecular Formula: C24H20BrNO4
• Molecular Weight: 466.331
• Mol File: 111934-06-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Morpholinecarboxylic acid, 3-bromo-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinecarboxylic acid, 3-bromo-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-(111934-06-6)
• EPA Substance Registry System: 4-Morpholinecarboxylic acid, 3-bromo-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-(111934-06-6)

Safety Data

• Hazardous Substances Data: 111934-06-6(Hazardous Substances Data)

Upstream product

• 100516-60-7 (1'S,2'R)-ethyl N-(benzyloxycarbonyl)-N-(1',2'-diphenyl-2'-hydroxyethyl)glycinate 
• 100678-82-8 2-((1S,2R)-2-hydroxy-1,2-diphenylethylamino)acetic acid ethyl ester 
• 23190-16-1 (1R,2S)-2-Amino-1,2-diphenylethanol 
• 100516-54-9 (5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 

Downstream Products

• 112741-67-0 (3S,5S,6R)-4-(benzyloxycarbonyl)-3-(2'-furanyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 112741-68-1 (3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-<2'-(5'-methylfuryl)>-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 112741-62-5 (3S,5S,6R)-3-(R)-Cyclopent-2-enyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester 
• 112741-61-4 (3S,5S,6R)-4(benzyloxycarbonyl)-3-(2'-cyclopentenyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 911222-16-7 (3R,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-<(ethoxycarbonyl)methyl>-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 113794-26-6 (3S,5S,6R)-3-Oct-1-ynyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester 
• 100516-55-0 (3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(2'-propenyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 111934-08-8 (3S,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one 
• 111934-07-7 (3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one 
• 112741-56-7 (3R,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-<2'-oxo-2'-(4-methoxyphenyl)ethyl>-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 112741-55-6 (3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-<2'-oxo-2'-(4-methoxyphenyl)ethyl>-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 112741-53-4 (3R,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(2'-oxo-2'-phenylethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 100516-57-2 (3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(2'-oxo-2'-phenylethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 112741-58-9 (3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylthio)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 

Relevant articles and documents

Practical Asymmetric Syntheses of α-Amino Acids through Carbon-Carbon Bond Constructions on Electrophilic Glycine Templates

The optically active D- and L-erythro-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) and D- and L-erythro-4-(tert-butoxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) can be efficiently brominated to serve as electrophilic glycine templates for the asymmetric synthesis of amino acids.It was found that coupling to these templates can proceed with either net retention or net inversion of stereochemistry.The final deblocking to the amino acids is accomplished with either dissolving-metal reduction or catalytic hydrogenolysis.The syntheses of β-ethyl aspartic acid, norvaline, allylglycine, alanine, norleucine, homophenylalanine, p-methoxyhomophenylalanine, cyclopentylglycine, and cyclopentenylglycine and a formal synthesis of clavalanine are described.In addition, the direct asymmetric syntheses of N-t-BOC-allylglycine and N-t-BOC-cyclopentenylglycine are described.