111934-22-6Relevant articles and documents
Direct Synthesis of N-Alkyl Arylglycines by Organocatalytic Asymmetric Transfer Hydrogenation of N-Alkyl Aryl Imino Esters
Mazuela, Javier,Antonsson, Thomas,Johansson, Magnus J.,Knerr, Laurent,Marsden, Stephen P.
, p. 5541 - 5544 (2017/10/25)
The organocatalytic asymmetric transfer hydrogenation of N-alkyl aryl imino esters for the direct synthesis of N-alkylated arylglycinate esters is reported. High yields and enantiomeric ratios were obtained, and tolerance to a diverse set of functional groups facilitated the preparation of more complex molecules as well as intermediates for active pharmaceuticals. A simple recycling protocol was developed for the Br?nsted acid catalyst which could be reused through five cycles with no loss of activity or selectivity.
