1119391-48-8

Basic information

• Product Name: 5-AMINO-3-PYRROLIDIN-1-YL-1H-PYRAZOLE-4-CARBONITRILE
• Synonyms: 5-AMINO-3-PYRROLIDIN-1-YL-1H-PYRAZOLE-4-CARBONITRILE
• CAS NO: 1119391-48-8
• Molecular Formula: C₈H₁₁N₅
• Molecular Weight: 177.21
• Mol File: 1119391-48-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-AMINO-3-PYRROLIDIN-1-YL-1H-PYRAZOLE-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3-PYRROLIDIN-1-YL-1H-PYRAZOLE-4-CARBONITRILE(1119391-48-8)
• EPA Substance Registry System: 5-AMINO-3-PYRROLIDIN-1-YL-1H-PYRAZOLE-4-CARBONITRILE(1119391-48-8)

Safety Data

• Hazardous Substances Data: 1119391-48-8(Hazardous Substances Data)

Usage

Uses

5-Amino-3-(pyrrolidin-1-yl)-1H-pyrazole-4-carbonitrile was identified in an experimental fragment-based screening of compounds that bind to the aspartic protease endothiapepsin by crystallography.

Upstream product

• 85106-63-4 2-((methylthio)(pyrrolidin-1-yl)methylene)malononitrile 

Downstream Products

• 940814-57-3 6-(2-hydroxybenzoyl)-2-pyrrolidin-1-ylpyrazolo[1,5-a]pyrimidine-3-carbonitrile 

Relevant articles and documents

A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles

The synthesis of novel 7-amino-substituted pyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles was achieved via a three-component reaction of 3-amino-substituted 5-aminopyrazole-4-carbonitriles, cyanamide and triethyl orthoformate under microwave irradiation.

NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.