111945-70-1

Basic information

• Product Name: Ethanone, 1-[2-(acetyloxy)-1-[(4-nitrobenzoyl)oxy]-3-cyclohexen-1-yl]-, cis-
• CAS NO: 111945-70-1
• Molecular Formula: C17H17NO7
• Molecular Weight: 347.324
• Mol File: 111945-70-1.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2-(acetyloxy)-1-[(4-nitrobenzoyl)oxy]-3-cyclohexen-1-yl]-, cis-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-(acetyloxy)-1-[(4-nitrobenzoyl)oxy]-3-cyclohexen-1-yl]-, cis-(111945-70-1)
• EPA Substance Registry System: Ethanone, 1-[2-(acetyloxy)-1-[(4-nitrobenzoyl)oxy]-3-cyclohexen-1-yl]-, cis-(111945-70-1)

Safety Data

• Hazardous Substances Data: 111945-70-1(Hazardous Substances Data)

Upstream product

• 1515-76-0 1-acetoxy-1,3-butadiene 
• 78209-93-5 3-(p-nitrobenzoyloxy)-3-buten-2-one 
• 1515-76-0 1-acetoxybuta-1,3-diene 

Downstream Products

• 125229-00-7 <1R*,2R*>-1-Acetyl-1,2-dihydroxycyclohex-3-ene 

Relevant articles and documents

Captodative olefin 3-p-nitrobenzoyloxy-3-buten-2-one as a Diels-Alder ketene equivalent for the synthesis of γ-hydroxycyclohexenones

A short and regioselective synthesis of γ-hydroxycyclohexenones is described, using 3-p-nitrobenzoyloxy-3-buten-2-one (2a) as a ketene equivalent in Diels-Alder reactions with substituted dienes. Oxidation with MCPBA of the α-acetylcyclohexenol derivative

Highly Selective Diels-Alder Cycloadditions of Captodative Dienophiles 1-Acetylvinyl Arenecarboxylates to Unsymmetrically Substituted Butadienes

Thermal Diels-Alder cycloadditions of captodative olefins 1-acetylvinyl arenecarboxylates, CH2=C(COCH3)OCOAr, 1a (Ar = C6H4pNO2), 1b (Ar = α-naphthyl), and 1c (Ar = β-naphthyl), with isoprene (2) were shown to be regioselective.This regioselectivity was greatly improved by using Lewis acids catalysis (ZnCl2, BF3*Et2O), the para adduct being the main isomer.The addition of dienophile 1a to 1-substituted dienes 3, 4, and 6 and 1,3-disubstituted butadiene 5 was highly regioselective too, and the ortho isomer was the only observed adduct.Stereoselectivity of these reactions was examined, and it was determined for all of these dienes, including the 1,4-diacetoxybutadiene (7), that the endo stereoisomer was obtained in a high proportion (> 80percent).The structure of major adducts 8a, 18a, 20a, 22a, 26a, and 29a was established by 1H and 13C NMR spectroscopy.Regioselectivity of these cycloadditions has been rationalized in terms of the FMO theory by MO calculations of dienophiles 1, using MINDO/3 and ab initio methods.It is suggested that secondary orbital interactions might be responsible for the observed endo selectivity.

REGIOSELECTIVITY OF DIELS-ALDER ADDITIONS OF 1-ACETYLVINYL ARENECARBOXYLATES

The Diels-Alder addition of "captodative" dienophiles 1-acetylvinyl arenecarboxylates 1b,1d and 1e to 1- and 2-substituted dienes was found highly regioselective.The rate and regioselectivity of this reaction were improved by Lewis acid catalysis.