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111964-21-7

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111964-21-7 Usage

General Description

Benzo[b]furan-3-carbonyl chloride is a chemical compound with the molecular formula C9H5ClO2. It is a derivative of benzo[b]furan, which is a heterocyclic compound containing a benzene ring fused to a furan ring. Benzo[b]furan-3-carbonyl chloride is a reactive compound known for its use as a versatile building block in organic synthesis, particularly in the synthesis of pharmaceuticals and agrochemicals. It is commonly used as an intermediate in the production of various chemicals and can undergo several types of chemical reactions, such as acylation, to form a variety of different compounds. Overall, benzo[b]furan-3-carbonyl chloride is an important chemical reagent with valuable applications in the field of organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 111964-21-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,9,6 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 111964-21:
(8*1)+(7*1)+(6*1)+(5*9)+(4*6)+(3*4)+(2*2)+(1*1)=107
107 % 10 = 7
So 111964-21-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H5ClO2/c10-9(11)7-5-12-8-4-2-1-3-6(7)8/h1-5H

111964-21-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-benzofuran-3-carbonyl chloride

1.2 Other means of identification

Product number -
Other names 3-benzofurancarboxylic acid chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:111964-21-7 SDS

111964-21-7Relevant articles and documents

Ni-catalyzed direct carboxylation of an unactivated C-H bond with CO2

Pei, Chunzhe,Zong, Jiarui,Han, Shanglin,Li, Bin,Wang, Baiquan

, p. 6897 - 6902 (2020)

The transition-metal-catalyzed direct carboxylation of an unactivated C-H bond is rarely reported, and no example of catalysis using abundant and cheap nickel has been reported. In this work, the first Ni-catalyzed direct carboxylation of an unactivated C-H bond under an atmospheric pressure of CO2 is reported. This method affords moderate to high carboxylation yields of various methyl carboxylates under mild conditions. Preliminary mechanistic studies reveal that a Ni(0)-Ni(II)-Ni(I) catalytic cycle may be involved in this reaction.

Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin

Lounsbury, Nicole,Eidem, Tess,Colquhoun, Jennifer,Mateo, George,Abou-Gharbia, Magid,Dunman, Paul M.,Childers, Wayne E.

supporting information, p. 1127 - 1131 (2018/02/21)

We recently discovered RnpA as a promising new drug discovery target for methicillin-resistant S. aureus (MRSA). RnpA is an essential protein that is thought to perform two required cellular processes. As part of the RNA degrasome Rnpa mediates RNA degradation. In combination with rnpB it forms RNase P haloenzymes which are required for tRNA maturation. A high throughput screen identified RNPA2000 as an inhibitor of both RnpA-associated activities that displayed antibacterial activity against clinically relevant strains of S. aureus, including MRSA. Structure-activity studies aimed at improving potency and replacing the potentially metabotoxic furan moiety led to the identification of a number of more potent analogs. Many of these new analogs possessed overt cellular toxicity that precluded their use as antibiotics but two derivatives, including compound 5o, displayed an impressive synergy with mupirocin, an antibiotic used for decolonizing MSRA whose effectiveness has recently been jeopardized by bacterial resistance. Based on our results, compounds like 5o may ultimately find use in resensitizing mupirocin-resistant bacteria to mupirocin.

Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4- one analogues as potent antitumor agents that inhibit tubulin assembly

Chang, Yu-Hsun,Hsu, Mei-Hua,Wang, Sheng-Hung,Huang, Li-Jiau,Qian, Keduo,Morris-Natschke, Susan L.,Hamel, Ernest,Kuo, Sheng-Chu,Lee, Kuo-Hsiung

experimental part, p. 4883 - 4891 (2010/02/28)

As part of our continuing investigation of azo-flavonoid derivatives as potential anticancer drug candidates, a series of 2-aryl-6,7- methylenedioxyquinolin-4-one analogues was designed and synthesized. The design combined structural features of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4- one (CHM-1), a previously discovered compound with potent in vivo antitumor activity, and 2-arylquinolin-4-ones, identified by CoMFA models. The newly synthesized analogues were evaluated for cytotoxicity against seven human cancer cell lines, and structure -activity relationship (SAR) correlations were established. Analogues 1, 37, and 39 showed potent cytotoxicity against different cancer cell lines. Compound 1 demonstrated selective cytotoxicity against Hep 3B (hepatoma) cells. Compound 37 was cytotoxic against HL-60 (leukemia), HCT-116 (colon cancer), Hep 3B (hepatoma), and SK-MEL-5 (melanoma) cells. Compound 39 exhibited broad cytotoxicity against all seven cancer cell lines, with IC50 values between 0.07 and 0.19 μM. Results from mechanism of action studies revealed that these new quinolone derivatives function as antitubulin agents.

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