111965-73-2Relevant articles and documents
Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer
Jin, Jianqiu,Zhu, Yucheng,Zhang, Zhenghe,Zhang, Weian
, p. 16354 - 16358 (2018)
Aggregation-induced quenching (AIQ) of photosensitizers greatly reduces the quantum yield of singlet oxygen generation and mitigates the efficacy of photodynamic therapy (PDT). We have prepared an alternating copolymer starting from 4-vinylbenzyl-terminated tetraphenylporphyrin (VBTPP) and maleimide isobutyl polyhedral oligomeric silsesquioxane (MIPOSS), via alternating reversible addition–fragmentation chain transfer (RAFT) polymerization. Porphyrin and POSS are installed on the amphiphilic block copolymers backbone in an alternating fashion and POSS completely inhibits the aggregation of porphyrin units via stacking. The amphiphilic block copolymer can self-assemble into nanoparticles and its application in PDT treatment was tested. These porphyrin-containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, providing a novel strategy to enhance the PDT efficacy.
Solid supported 9-amino-9-deoxy-epi-quinine as efficient organocatalyst for stereoselective reactions in batch and under continuous flow conditions
Porta, Riccardo,Benaglia, Maurizio,Coccia, Francesca,Cozzi, Franco,Puglisi, Alessandra
, p. 377 - 383 (2015)
Polystyrene-supported 9-amino-9-deoxy-epi-quinine was synthesized through co-polymerization of an ad hoc-designed chiral monomer with divinylbenzene, in the presence of azobis(isobutyronitile) (AIBN) as radical initiator and toluene and 1-dodecanol as porogenic solvents. The heterogenized catalyst efficiently promoted the reaction of isobutyric aldehyde with b-nitrostyrene, in very high yield and enantioselectivity, comparable or even higher than that of the homogeneous counterpart (up to 95% ee). The recyclability of the catalyst, its general applicability and its successful application to other reactions was also demonstrated. Finally, for the first time, a 9-amino- epi-quinine derivative was employed to perform an enantioselective Michael reaction under continuous-flow conditions; by using a home-made, packed-bed catalytic reactor, the aldehyde addition to nitrostyrene was successfully realized in flow mode, leading to the product in up to 93% ee.
Synthesis of azide-functionalized nanoparticles by microemulsion polymerization and surface modification by click chemistry in aqueous medium
Ouadahi, Karima,Allard, Emmanuel,Oberleitner, Birgit,Larpent, Chantal
, p. 314 - 328 (2012)
Stable translucent aqueous suspensions of azide-functionalized cross-linked nanoparticles (NPs), with diameters in the 15-20 nm range, were prepared using two synthetic approaches. Copolymerization of azidomethylstyrene (VBN 3), styrene, and di
Catalytic Staudinger Reduction at Room Temperature
Lenstra, Danny C.,Wolf, Joris J.,Mecinovi?, Jasmin
, p. 6536 - 6545 (2019/05/24)
We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.
Reactive polymer zwitterions: Sulfonium sulfonates
Santa Chalarca, Cristiam F.,Emrick, Todd
, p. 83 - 92 (2016/11/29)
Sulfonium sulfonate, or sulfothetin, zwitterionic monomers were synthesized by ring-opening of 1,3-propanesultone with dialkyl sulfides containing styrenic or methacrylic moieties. Reversible addition-fragmentation chain-transfer polymerization of these m
