1119782-78-3Relevant academic research and scientific papers
Synthesis and structure-activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents
Giraud, Francis,Guillon, Remi,Loge, Cedric,Pagniez, Fabrice,Picot, Carine,Borgne, Marc Le,Pape, Patrice Le
experimental part, p. 301 - 304 (2011/02/26)
Continuous efforts on the synthesis and structure-activity relationships (SARs) studies of modified 1-benzylamino-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents, allowed identification of new 1-[(pyridinyl- and piperidinylmethyl)amino] derivatives with MIC80 values ranging from 1410.0 to 23.0 ng mL-1 on Candida albicans. These results confirmed both the importance of π-π stacking and hydrogen bonding interactions in the active site of CYP51-C. albicans.
